Cancer Proteomics

The cinnamaldehyde derivative CB403 staunches mitosis to kill cancer cells

Published in Cancer Weekly, June 17th, 2003

The cinnamaldehyde derivative CB403 staunches mitosis to kill cancer cells.

"Cinnamaldehydes have been shown to have inhibitory effects on farnesyl protein transferase (FPTase; EC 2.5.1.29) in vitro, angiogenesis, cell-cell adhesion, and tumor cell growth and to be immunomodulators. However, the mechanisms responsible for these effects remain unknown," scientists in South Korea report.

"To elucidate the molecular mechanism of the cinnamaldehyde derivative CB403 for growth inhibition, CB403 was synthesized from 2'-hydroxycinnamaldehyde. CB403-treated cells were weakly adherent to the culture dishes. In addition, CB403 inhibited tumor growth in these...

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Source: Cancer Weekly (2003-06-17)

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