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Acute Lymphoblastic Leukemia

Rituximab with stem cell autografts effective after relapse

Published in Cancer Weekly, June 17th, 2003

In combination with stem cell autotransplantation, the monoclonal antibody rituximab is effective for children with relapsed acute lymphoblastic leukemia (ALL).

"Childhood B-cell neoplasms account for approximately 2%" of pediatric ALL cases, scientists in Switzerland explained. "The short but intensive chemotherapy yields a currently 75% to 85% event-free survival."

However, "the prognosis for children with relapsed disease is considered to be dismal," according to S. Corbacioglu and coauthors at the University of Zurich, who described their experience with "a 12-year old boy diagnosed with B-cell ALL with central nervous system (CNS)...

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