Oncology
Tempol is a potential new therapy for the treatment of glioma
Published in Cancer Weekly, June 24th, 2003
"The identification of novel therapeutic agents for the management of malignant gliomas represents an area of active research. Here, we show that Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl; TPL), a stable nitroxide free radical, inhibits the growth of C6 glioma cells both in vitro and in vivo. Morphological features of apoptosis were apparent in C6 cells following in vitro treatment with TPL," investigators in Italy reported.
"Cell death was preceded by dose-dependent increase in p21(waf1/cip1) expression, without apparent stabilization of the TP53 gene product. When C6 cells...
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Source: Cancer Weekly (2003-06-24)
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