B-Cell Cancers

Transcription factor expression shows genetic relationships of Hodgkin lymphomas

Published in Cancer Weekly, June 24th, 2003

The genetic relationship of B cells to Hodgkin lymphoma types is further elucidated, and a possible progression identified.

According to published research from Germany, "The World Health Organization (WHO) classification of Hodgkin lymphoma (HL) distinguishes 2 types: Classical Hodgkin lymphoma (CHL) and nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). Both groups have in common that they mostly derive from B cells with rare classical cases originating from T cells. They differ in their histomorphology, immunophenotype, and clinical behavior.

"One of the subtypes of CHL, designated as lymphocyte-rich classical Hodgkin lymphoma (LRCHL),...

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Source: Cancer Weekly (2003-06-24)

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