Prostate Cancer

Androgen-induced cell proliferation may not be mediated by ERK1/2 activation

Published in Cancer Weekly, June 24th, 2003

Data from a study by University of Alabama pathologists suggest that androgen-induced prostate cancer cell proliferation may not be mediated by extracellular signal-regulated kinase 1/2 activation.

"The mechanisms by which androgens stimulate proliferation of prostate cancer cells are poorly understood. It has been proposed that androgen stimulation may induce the mitogen-activated protein (MAP) kinase system in prostate cancer cells and lead to cellular proliferation," wrote W.C. Bell and colleagues.

In their study, they sought "to evaluate the role of the extracellular signal-regulated kinase (ERK) pathway in the stimulation by androgens of...

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Source: Cancer Weekly (2003-06-24)

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