Proteomics
Ceramide may be important target in antineoplastic strategies
Published in Cancer Weekly, June 24th, 2003
"The sphingolipid ceramide has proven to be a powerful second-signal effector molecule that regulates diverse cellular processes including apoptosis, cell senescence, the cell cycle, and cellular differentiation," scientists in the United States report.
"Ceramide has been shown to activate a number of enzymes involved in stress signaling cascades including both protein kinases and protein phosphatases. Ceramide kinase targets include stress-activated protein kinases (SAPKs) such as the jun kinases (JNKs), kinase suppressor of Ras (KSR), and the atypical protein kinase C (PKC) isoform,...
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Source: Cancer Weekly (2003-06-24)
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