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Systemic Amyloidosis

Gastrointestinal stromal tumors may occasionally lead to amyloid deposition

Published in Cancer Weekly, June 24th, 2003

Gastrointestinal stromal tumors appear to occasionally lead to diffuse systemic amyloidosis.

According to a study from the United States, "A 69-year-old man presented with a malignant gastrointestinal stromal tumor associated with secondary amyloidosis. The tumor had classic features of a malignant gastrointestinal stromal tumor with interlacing fascicles and whorls of spindle cells, numerous conspicuous mitotic figures, and extensive coagulative necrosis. Cells stained diffusely for CD117 (c-Kit), confirming the diagnosis of gastrointestinal stromal tumor.

"The spleen, one adrenal gland, and part of the pancreas were removed en block with the...

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