Cancer Weekly

Cancer Metastasis - Researchers successfully inhibit spread of cancer in mice

Cancer Therapy - Engineered adenoviruses selectively destroys tumor cells

AIDS-related Lymphoma - HAART appears to have caused biological shift towards more treatable disease

Apoptosis - Silent DNA architecture helps block cancer cell growth

Prostate Cancer - 'Lost' protein may lead to new treatment

Women's Health - Primary ovarian cancer spheroids host replicative adenovirus targeting integrin

Acute Lymphoblastic Leukemia - Unrelated stem cell grafts improve survival for children with high recurrence risk

Acute Myelogenous Leukemia - More cytokines are produced by circulating lymphoid and myeloid cells in AML

Acute Myeloid Leukemia - Gemtuzumab ozogamicin may be effective for pediatric patients

Adrenal Cancer - The adrenal cortex is controlled by fragments from the same mother peptide

Anemia in Malignancy - Epoetin beta therapy significantly improves quality of life in anemia

Angiosarcoma - Spontaneous pneumothorax can occur as the first sign of metastatic angiosarcoma

Antiangiogenesis - Viper venom derivative obtustatin suppresses angiogenesis in laboratory studies

Antiglioblastoma Therapy - EGF-positive cancer may be treatable with diptheria toxin-EGF fusion protein

Antitumor Agents - Two coumarin derivatives may serve as new lead compounds of antitumor agents

Antitumor Components -  Myrica rubra var. acuminata has antitumor constituents

Apoptosis - Caspase inhibition switches doxorubicin-induced apoptosis to senescence

Apoptosis - ErPC triggers apoptosis via Bcl-2-dependent mitochondrial pathway

Apoptosis - Salicylate potentiates necrotic, apoptotic cell death in colon, lung, breast

Apoptosis Research - Background reduced in apoptosis studies by combining TUNEL kit, imaging system

Atopic Disease - The risk for childhood acute lymphoblastic leukemia is diminished with allergy

Autoimmune Disease - Patients testing positive for anti-Hu antibodies may have underlying cancer

Bile Duct Carcinoma - Annular pancreas can be complicated by carcinoma of the bile duct

Bladder Cancer Prognosis - Ki-67 index is a cell cycle marker; enhances prognostic accuracy of risk groups

Bone Marrow Transplantation - BMT can be successful in subjects with mental disorders

Bone Marrow Transplantation - Survival not substantively affected by depressed mood or other psychopathology

Bone Metastases - Test identifies patients at high risk of bone complications

Brain Cancer - PTEN reduces glioma vascularization despite angiogenic stimuli

Brain Cancer - Phase III data for brain metastases available

Brain Cancer - Research may lead to blood test for brain tumor diagnosis

Brain Tumors - MRI may distinguish hemangioblastomas from other cerebellar tumors

Brain Tumors - Researchers reprogram genetic material to reverse cancer

Brain Tumors - TMEFF1 may behave as a tumor suppressor gene in brain cancers

Breast Cancer - Age, education, and country of birth may be a subgroup vulnerable to depression

Breast Cancer - Antioxidants and vitamins may reduce estrogen-associated breast cancer risk

Breast Cancer - Antitumor activity reported for ABI-007 in patients resistant to taxane

Breast Cancer - Careful standardization needed for multicenter breast cancer genetic screening

Breast Cancer - Cases in U.K. top 40,000 for first time

Breast Cancer - Epirubicin clinical trial shows treatment improves survival rate

Breast Cancer - Increased expression of the Bfl-1 gene may contribute to breast cancer

Breast Cancer - Information may help identify early environmental exposures that increase risk

Breast Cancer - Inherited vulnerability to hormones of puberty may be a cause of disease

Breast Cancer - It may be therapeutic for breast cancer patients to express negative emotions

Breast Cancer - National breast cancer foundation comments on MRI diagnostics

Breast Cancer - New chemotherapy agent highlighted in oncology studies

Breast Cancer - PTHrP expression is predictive of longer survival in breast cancer

Breast Cancer - Phase II study shows strong clinical responses

Breast Cancer - Rb2 gene may play role in determining effectiveness of drug therapies

Breast Cancer - Researchers evaluate economics of specialized breast cancer center

Breast Cancer - Shared decision making in breast cancer patients is evaluated

Breast Cancer - Tumor-bed boost with brachytherapy can provide satisfactory local control

Breast Cancer - Two forms of fibulin-1 protein are upregulated by malignant breast cancer tissue

Breast Cancer Risk Factor - High dietary (n-3)/(n-6) fatty acid ratio lowers breast cancer risk

Breast and Ovarian Cancer - Social support buffers both negative physical and psychological outcomes

Cancer - New clinical trial data presented

Cancer Biomarkers - Angiogenesis quantification needs streamlining if predictive value is the goal

Cancer Immunotherapy - Growth factor regulation may block tumor entry by immune effector cells

Cancer Immunotherapy - Vaccine based on high-affinity receptor suppresses tumor angiogenesis

Cancer Paradigm - Invasion or proliferation, but not both, occur in malignant basal cell carcinoma

Cancer Proteomics - CD105 prevents suicide in endothelial cells held under hypoxic conditions

Cancer Proteomics - Heparan sulfate proteoglycans regulate angiogenic signals in brain endothelium

Cancer Therapy - A model optimizes scheduling for radiotherapy and angiogenesis inhibitors

Cancer Therapy - Advexin therapy halts tumor growth in advanced esophageal cancer patients

Cancer Therapy - Company shows promising treatment for soft tissue sarcoma

Cancer Therapy - Data about Quadramet in hematological and solid tumor cancers presented at ASCO

Cancer Therapy - Data suggest risk of infection doubles with reduced Neupogen administration

Cancer Therapy - Early data show positive indicators of antitumor activity with gimatecan

Cancer Therapy - EntreMed and Corvas scientists identify new cancer target

Cancer Therapy - Favorable phase I results of KOS-862 (Epothilone D) presented at ASCO

Cancer Therapy - GenOdyssee presents preclinical results of interferon alpha variants

Cancer Therapy - Genaera announces promising interim lung cancer clinical trial results

Cancer Therapy - IMiDs demonstrate potential activity in solid tumors

Cancer Therapy - Leukemia cells internalize specific antibodies that could be linked to toxin

Cancer Therapy - Lorus publishes results of GTI-2040 antitumor activity

Cancer Therapy - New clinical findings announced for NeoLipid anticancer compounds

Cancer Therapy - Phase III results enhances treatment for pancreatic cancer patients

Cancer Therapy - Research shows weight gain, safety in treatment of cancer

Cancer Therapy - Trials show early signs of tolerability for RAF kinease inhibitor

Cancer Therapy - Vascular targeting agent proves effective in cancer treatment

Cancer Treatment - Gene therapy important part of cancer research

Cancer Vaccine - Antitumor immunity induced by electrofusion of tumor and dendritic cells

Cancer Vaccine - Apoptosis plus CD80 costimulation promote immune response by melanoma cells

Cancer and Depression - Appetite symptoms and diminished thinking ability may indicate depression

Carcinogenesis - Adenomatous polyposis coli and E-cadherin are downregulated in colorectal cancer

Carcinogenesis - Cadmium studies suggest new pathway to human cancer

Cell Biology - Columnar cell lesions of the breast can be classified by a simplified scheme

Cell Death - Distinct mechanisms exist for proapoptotic effects of cPG in endothelial cells

Cervical Cancer - There is a low risk of cervical cancer for several years after a negative Pap

Chemotherapy - Dinuclear ruthenium complexes can regulate the cell cycle of tumor cells

Chemotherapy - RDP58 allows higher dosing of chemotherapy without increased GI toxicities

Chemotherapy - The alpha integrin inhibitor cilengitide is deemed safe in a phase I trial

Childhood Cancer - Fetal mouse genetic and epigenetic mechanisms modulated by cigarette smoke

Cholangiocarcinoma - Photofrin PDT studied for treatment of malignancy in ducts

Choriocarcinoma Cell Line - The uptake of H-3-5HT by JAR cells occurs exclusively through SERT

Collaborations - Cytokine variants licensed for development

Collaborations - U.K., French companies collaborate on anticancer therapy discovery

Colon Cancer - ImClone Systems and Bristol-Myers discuss Erbitux with FDA

Colon Cancer - Methylation-induced G₂ /M arrest requires a full complement of hMLH1

Colorectal Adenomas - A high ratio of fish fatty acids to arachidonic acid lowers colon cancer risk

Colorectal Cancer - Study: RF technology increases survival rates colon cancer

Colorectal Carcinoma - FADD interacts with methyl-CpG binding domain protein

Colorectal Lymphoma - The first case of primary colorectal T-cell lymphoma is reported

Corporate Update - Oncology drug company reports personnel changes, launch of phase III trials

DNA Damage - Exposure to one, minimal erythema dose of UV damaged skin DNA of all subjects

Drug Design - Therapeutic antibodies for targeted treatment of cancer are the next generation

Drug Development - Corporate update provided for U.K.-based biotech

Endocrinology - Results of new survey links metabolic type with cancer and diabetes

Endometrial Cancer - Tibolone exerts progestagenic effects on human endometrial cancer cells

Epidemiology - WHO: Concerted global action is the only answer to rising cancer deaths

Familial Cancer - Genomic rearrangements account for more than one-third of the BRCA1 mutations

Familial Cancer - Ratio of reported-to-expected cancer rates in family members approximately 0.7

Finance - Cancer drug company issues share conversion notice