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Acute Lymphoblastic Leukemia

Unrelated stem cell grafts improve survival for children with high recurrence risk

Published in Cancer Weekly, July 1st, 2003

Unrelated stem cell grafts improve survival chances for children with high-risk acute lymphoblastic leukemia (ALL).

"Allogeneic stem cell transplantation (SCT) is frequently considered as treatment for relapsed childhood" ALL, researchers in Germany explained. "For patients without a matched sibling donor, SCT from unrelated donors (UD-SCT) has been increasingly performed during the past years."

"However, UD-SCT-related mortality and morbidity is still considerable, and the question remains as to which patients are at such high risk of recurrence that UD-SCT is indicated and, conversely, which patients do not require transplantation for long-term...

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