Acute Myeloid Leukemia

ETO domain responsible for oncogenic effects of AML1-ETO

Published in Cancer Weekly, July 15th, 2003

The ETO domain is responsible for the AML1-ETO fusion protein's oncogenic effects.

"Translocation of the ETO gene on human chromosome 8 with the AML1 gene on chromosome 21 (AML1-ETO) is a recurrent cytogenetic abnormality associated with approximately 12% of acute myelogenous leukemia (AML) cases," researchers in the United States explained.

"To understand the contribution of the t(8:21) to AML," C.G. de Guzman and coauthors at the University of Alabama "transduced purified hematopoietic stem cells (HSC) with a retroviral vector that coexpressed AML1-ETO or just the AML1 portion (AMLId) of the translocation along with a green...

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Source: Cancer Weekly (2003-07-15)

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