Leukemia
NUP98-HOXD13 can be implicated in leukemic transformation
Published in Cancer Weekly, July 22nd, 2003
"HOX genes, notably members of the HOXA cluster, and HOX cofactors have increasingly been linked to human leukemia," investigators in Canada report.
"Intriguingly, HOXD13, a member of the HOXD cluster not normally expressed in hematopoietic cells, was recently identified as a partner of NUP98 in a t(2;11) translocation associated with t-AML/MDS. We have now tested directly the leukemogenic potential of the NUP98-HOXD13t(2; 11) fusion gene in the murine hematopoletic model," wrote N. Pineault and colleagues, British Columbia Cancer Agency, Terry Fox Laboratory.
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Source: Cancer Weekly (2003-07-22)
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