Immunology
Antibody to xenogeneic endothelial cells causes apoptosis and dismantles tumors
Published in Cancer Weekly, July 22nd, 2003
"In this study, we demonstrate that vaccination of rabbits with murine endothelial cells yields polyclonal immunoglobulin (IgG) with potent antiangiogenic activity. The mechanism of this response appears to be through apoptosis of endothelial cells in vitro. Induction of polyclonal IgG in a xenogeneic host may be useful in passive immunotherapy of a variety of cancers," investigators in the United States report.
"In fact, the antibody showed antitumor activity in three mouse tumor models (murine B16F10 melanoma, murine SVR angiosarcoma, and human DLD-1 colorectal...
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Source: Cancer Weekly (2003-07-22)
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