Breast Cancer
HRG/M sequences are sufficient to sensitize MCF-7 cells to doxorubicin
Published in Cancer Weekly, July 29th, 2003
According to a study from the United States, "Heregulin (HRG) is an activator of the erbB2-, erbB3- and erB4-(erbB-2/3/4) signaling pathway.
"Transfection of full-length HRG cDNA into the estrogen (E2)-dependent cell line MCF-7 promoted an invasive E2-independent phenotype, as well as persistent activation of the erbB-2/3/4 receptors. Moreover, HRG expression in MCF-7 cells renders the cells sensitive to the topoisomerase 11 inhibitor doxorubicin (Doxo)," wrote E. Atlas and colleagues, Northwestern University, Evanston Northwestern Healthcare Research Institute.
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Source: Cancer Weekly (2003-07-29)
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