Leukemia

BCR/ABL blast amplification may have role in blast transformation

Published in Cancer Weekly, August 5th, 2003

BCR/ABL blast amplification may have role in blast transformation.

According to published research from Argentina, "Although the chronic phase of chronic myelocytic leukemia (CML) is characterized by the Philadelphia (Ph) chromosome creating a hybrid BCR/ABL gene, additional genetic changes involved in blast crisis are poorly understood.

"We report a 4-8-fold amplification by tandem duplication of the BCR/ABL fusion gene clustered on a masked Ph chromosome in a 61-year-old male patient with CML in myeloblastic crisis," wrote P.M. Gargallo and colleagues, National Academy of Medicine, Buenos Aires, Department of Genetics.

"Our...

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Source: Cancer Weekly (2003-08-05)

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