Published in Cancer Weekly, August 5th, 2003
According to published research from Argentina, "Although the chronic phase of chronic myelocytic leukemia (CML) is characterized by the Philadelphia (Ph) chromosome creating a hybrid BCR/ABL gene, additional genetic changes involved in blast crisis are poorly understood.
"We report a 4-8-fold amplification by tandem duplication of the BCR/ABL fusion gene clustered on a masked Ph chromosome in a 61-year-old male patient with CML in myeloblastic crisis," wrote P.M. Gargallo and colleagues, National Academy of Medicine, Buenos Aires, Department of Genetics.
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