Leukemia

Mutations in PTPN11 associated with JMML caused a gain of function

Published in Cancer Weekly, August 5th, 2003

Mutations in PTPN11 associated with JMML caused a gain of function.

"We report here that individuals with Noonan syndrome and juvenile myelomonocytic leukemia (JMML) have germline mutations in PTPN11 and that somatic mutations in PTPN11 account for 34% of non-syndromic JMML," scientists in the United States report.

"Furthermore, we found mutations in PTPN11 in a small percentage of individuals with myelodysplastic syndrome (MDS) and de novo acute myeloid leukemia (AML)," wrote M. Tartaglia and colleagues, CUNY Mt Sinai School of Medicine, Department of Pediatrics.

The researchers concluded: "Functional analyses documented that the...

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Source: Cancer Weekly (2003-08-05)

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