Oncology
The CXCL9 gene generates angiogenesis-independent antitumor effects
Published in Cancer Weekly, August 5th, 2003
"We examined whether expression of monokine induced by IFN-gamma (Mig, CXCL9) in tumors could produce antitumor effects. Murine lung carcinoma cells (A11) were retrovirally transduced with the murine Mig gene (A11/ Mig) and were inoculated into syngeneic mice. Although proliferation in vitro of A11/Mig cells was not different from that of parent cells, the growth in vivo of A11/Mig tumors was significantly retarded compared with that of parent tumors," researchers in Japan reported.
"The antitumor effect was dependent on the amount of Mig produced. We compared the expression level...
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Source: Cancer Weekly (2003-08-05)
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