Prostate Cancer
Translation inhibitors sensitize prostate cancer cells to apoptosis
Published in Cancer Weekly, August 5th, 2003
According to a study from the United States, "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in several human tumors both in vitro and in vivo, however, some tumors remain resistant for poorly understood reasons.
"Using a quantitative DNA fragmentation assay for apoptosis, we have shown that human prostate cancer cells are resistant to a wide range of TRAIL doses up to 500 ng/ml. However, translation inhibitors, such as anisomycin, cycloheximide, emetine, harringtonine, and puromycin, unlike several transcription inhibitors, significantly...
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Source: Cancer Weekly (2003-08-05)
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