Risk Factors

MCUL is probably a genetically homogeneous tumor predisposition syndrome

Published in Cancer Weekly, August 5th, 2003

MCUL is probably a genetically homogeneous tumor predisposition syndrome.

According to published research from England, "Germline mutations of the fumarate hydratase (FH, fumarase) gene are found in the recessive FH deficiency syndrome and in dominantly inherited susceptibility to multiple cutaneous and uterine leiomyomatosis (MCUL).

"We have previously reported a number of germline FH mutations from MCUL patients. In this study, we report additional FH mutations in MCUL and FH deficiency patients," wrote N.A. Alam and colleagues, Cancer Research UK, Molecular & Population Genetics Laboratory.

"Mutations can readily be found in...

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Source: Cancer Weekly (2003-08-05)

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