Breast Cancer

Study seeks women with recurring disease to test new antibody

Published in Cancer Weekly, August 5th, 2003

The University of California, Los Angeles, Jonsson Cancer Center is testing an experimental immune system-boosting antibody that could one day help women who have not responded to conventional chemotherapy treatments for metastatic breast cancer.

The Phase I study uses an antibody directed at the MUC1 protein, which is exposed on the surface of cancer cells in more than 90% of women who have breast cancer. In normal tissues, MUC1 is a protein that is literally sugar-coated, being completely surrounded by carbohydrate molecules. In rapidly growing cancer cells, the sugar structures do not form correctly and the protein core of MUC1 is exposed. Researchers believe this...

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Source: Cancer Weekly (2003-08-05)

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