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Cancer Therapy

17-AAG shows synergistic anticancer activity with leading chemotherapeutic agent

Published in Cancer Weekly, August 5th, 2003

Kosan Biosciences, Inc., (KOSN) presented results of a preclinical study of 17-allylamino-17-demethoxygeldanamycin (17-AAG), at the 94th annual meeting of the American Association for Cancer Research (AACR).

Study findings demonstrate that 17-AAG and 5-fluorouracil (5-FU) administered in combination against human colon cancer cell lines results in a synergistic growth inhibiting effect.

According to study investigators, the combination of 17-AAG and 5-FU warrants further investigation as an anticancer therapy. Kosan and the National Cancer Institute (NCI) are collaborating to codevelop 17-AAG and other geldanamycin derivatives, and are planning to...

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