Oncology
Tumor-associated gangliosides modulate biological behaviors in tumors
Published in Cancer Weekly, August 5th, 2003
According to a study from France, "neuroectodermic tumors can mostly be characterized by the presence of tumor-associated glycosphingolipid antigens, such as gangliosides, defined by monoclonal antibodies. Recently, cumulative evidence indicates that gangliosides modify the biological effects of several trophic factors, in vitro and in vivo, as well as the mitogenic signaling cascade that these factors generate."
"The functional roles of gangliosides in tumor progression can be revisited:
i) ganglioside antigens on the cell surface, or shed from the cells, act...
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Source: Cancer Weekly (2003-08-05)
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