Squamous Cancer

PD-ECGF causes head and neck cancers to cycle through growth phases quickly

Published in Cancer Weekly, August 5th, 2003

PD-ECGF causes head and neck cancers to cycle through growth phases quickly.

"Platelet-derived endothelial cell growth factor (PD-ECGF) was isolated as an endothelial mitogen from platelets and demonstrated to have angiogenic activity and thymidine phosphorylase (TP) activity. It was reported that the overexpression of PD-ECGF occurred with the rapid tumor growth in vivo. In this study, we transfected PD-ECGF into the head and neck squamous cell carcinoma cell line IMC-3 and investigated the property of transfectants in vitro," scientists in Japan reported.

"Highly overexpressed PD-ECGF transfectants rapidly grew compared with parental cells and...

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Source: Cancer Weekly (2003-08-05)

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