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Cancer Weekly

Susan Hasty, Publisher

Table of Contents . . . August 12th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Weekly | Other Publications

Cancer Immunity - Spontaneous and full recovery from advanced cancers is found in mouse model

Oncology - A new cytokine cocktail reduces melanoma growth in mice

Brain Cancer - Researchers detail events that enable brain tumors to weaken immune system

Breast Cancer - Value of radiation confirmed in early-stage disease

Cancer Vaccine - A syngeneic endothelial cell vaccine jumpstarts antitumor immunity in mice

Depression - Symptoms signal shorter lives for people with cancer

Lung Cancer - Taxotere with cisplatin provides better 2-year survival rate

Mesothelioma - Keratin 19 enhancer-promoter sequences enhance suicide gene therapy

Physician Practice - Doctors use confusing language in cancer consultations

Anemia and Cancer - Anemia in cancer patients can be treated with transfusion, erythropoietin

Anemia and Cancer - Anemia of cancer can occur before any treatment begins

Anticancer Therapy - Monoclonal antibodies are large portion of drugs in development

Apoptosis - Apoptosis triggered redistribution of caspase-9 from cytoplasm to mitochondria

Awards - Keck Foundation names distinguished young scholar in medical research

B-Cell Generation - Bcl11a (Evi9) is an essential component for proper immune system development

Bone Cancer - Peripheral opioids act as analgesics in bone cancer pain in mice

Brain Tumors - Glutamine transport in C6 glioma cells shows ASCT2 system characteristics

Brain Tumors - Putative tumor suppressor gene KLF6 is mutated in astrocytic gliomas

Brain Tumors - Waterjet used in the resection of brain metastases

Breast Cancer - Anti-idiotype antibody elicits antibody response in breast cancer patients

Breast Cancer - Genetics, relationship to dietary folate and alcohol are focus of study

Breast Cancer - JNK/SAPK pathway activation may be a therapeutic intervention in breast cancer

Breast Cancer - MR imaging and mammography are good measures of invasive breast malignancy

Breast Cancer - Mammography in women over 40 catches disease earlier

Breast Cancer - Mutant p53 and aberrant cytosine methylation silence gene expression

Breast Cancer - No association in polymorphisms in ERbeta gene and risk of breast cancer

Breast Cancer Screening - American Cancer Society updates guidelines for breast cancer screening

CNS Tumors - Inhibition of signaling pathways may represent promising therapeutic strategies

Cancer Drug Toxicity - Two anticancer agents may help reduce platinum-, taxane-associated toxicities

Cancer Immunotherapy - Human antiglobulin antibody response to foreign antibody may not be bad

Cancer Risk - Folic acid supplements may reduce vascular disease and cancer

Cancer Screening - People need more encouragement to get routine screenings

Cancer Therapy - Therapeutic strategies that target NK4 look promising for preventing metastasis

Cancer Transmission - Researchers give screening guidelines for infants born to women with cancer

Cancer Vaccine - Dendritic cell vaccines offer new hope for treatment of endocrine tumors

Cancer Vaccine - Dendritic cells prevent metastasis of HPV 16-associated tumors

Cancer Vaccine - Oncolytic adenoviral vector expressing GM-CSF exhibits anti-tumor activity

Cancer Vaccine - RNA transfection of dendritic cells induces immunity against breast cancer

Cell Proliferation Marker - Serine palmitoyltransferase may be a molecule involved in metastasis

Cervical Carcinoma - Leukemoid reaction can occur in association with cervical carcinoma

Cervical Malignant Melanoma - Primary malignant melanoma of the uterine cervix is rare

Chronic Myelogenous Leukemia - Imantinib enhances antileukemia effect of dendritic cells

Chronic Myelogenous Leukemia - Imatinib treatment does not eradicate malignant stem cells in CML patients

Chronic Myeloid Leukemia - Canadian phase I/II study for Theralux completed

Clear-Cell Sarcoma - Fine-needle aspiration yields melanin, confirming diagnosis

Collagen Imaging - Dynamic imaging of collagen in mice accomplished with second-harmonic generation

Colon Cancer - Virtual colonoscopy procedure offered as a stand-alone service

Colorectal Cancer - New research study suggests PEG-based laxatives may prevent colorectal cancer

Colorectal Cancer - Night-shift work may increase risk of colorectal cancer in women

Diarrhea - Trial shows biotherapeutic agent effective in treating GI problems

Dietary Supplements - Little known about risks and benefits of long-term supplement use

End-of-Life Care - Doctors overestimate survival of terminally ill patients

Endocrinology - Plasminogen activation by endostatin encourages endothelial cell detachment

Enzymology - Histone deacetylase inhibitors arrest MMP-2 activity to stop cancer invasion

Enzymology - Human PAR1 influences the metastatic potential of cancer

Epstein-Barr Virus - Paper reveals secrets of a cancer virus

Esophageal Neoplasm - Rare mesenchymal neoplasm of the esophagus develops in a child

Finance - Oncology company raises $9.6M

Gastric Cancer - COX-2 correlates with VEGF-A and tumor angiogenesis in gastric cancer

Gastroenterology - Cyclin D1 overexpression in normal cells may cause oncogenic transformation

Head and Neck Cancer - Angiogenesis is not the only tumor growth mechanism targeted by endostatin

Head and Neck Cancer - Excess apoptosis may predict worse outcomes in laryngeal cancer patients

Head and Neck Cancer - Extracranial-intracranial bypass reconstructs the internal carotid artery

Head and Neck Cancer - The effects of endostatin extend beyond angiostatic influence

Hepatocellular Carcinoma - COX-2 inhibition may offer a new approach for HCC chemoprevention

Hodgkin Disease - Cutaneous granulomas appear as the first manifestation of Hodgkin's disease

Immunology - Colon cancer cells that express interleukin-23 generate systemic immunity

Immunology - Data about B cell lymphoma vessel density hinges on staining specifics

Immunology - Gene modified cytotoxic T lymphocytes present anticancer possibilities

Immunology - Some T-cell and immunological defects might stem from VEGF overexpression

Kaposi Sarcoma - HHV-8 open reading frame mutations can aid study of Kaposi sarcoma development

Leukemia - Adenine analogs may be differentiation therapy agents for acute myeloid leukemia

Leukemia - Insertion of MLL sequences is a rare abnormality associated with infant leukemia

Leukemia - Neurologic complications occur in children receiving L-asparaginase for ALL

Leukemia and Lymphoma - B cells with aberrant markers along with CD19 indicate increased patient risk

Lip Cancer - Localization in commissure is a risk factor for metastasis in lip cancer

Liver Cancer - Inhibition of the paternal gene PEG10 might abate hepatocellular carcinogenesis

Liver Cancer - VEGF and angiopoietin 2 are linked to hepatocellular carcinoma vascularity

Lung Cancer - It is important to attend to physical, emotional needs of lung cancer survivors

Lung Cancer - Topotecan has established antitumor activity in recurrent SCLC

Lymphoma - CHASE effective as salvage chemotherapy regimen for lymphoma patients

Lymphoma Therapy - Stem cell transplantation successful in patient with central nervous system lymphoma

Lymphopoiesis - Alpha beta T lymphocyte development depends on Bcl11b

Lymphotropic Herpesviruses - Antiviral susceptibility utilizing flow cytometry is an efficient testing method

Malaria Therapy - Novel tetraoxanes active against malaria and some tumors

Medullary Thyroid Cancer - Hormones in MTC are markers and may mediate biological effects in tumor growth

Melanoma - Hawaii melanoma rate on rise

Melanoma - Positive preclinical results reported with humanized antibodies

Melanoma - Proliferation rates in melanoma can identify patients with poor outcomes

NK Killing Signals - NKG2D-DAP10 can activate NK killing without ITAM or Syk involvement

Neuroscience - Incessant atrial tachycardia resolves after removal of a cerebral tumor

Nicotine Addiction - Measurements of "free-base" nicotine in cigarette smoke described

Obesity Survival and Mortality - Obesity may reduce efficacy of high-dose chemotherapy

Oncogenes - Researchers pinpoint genes involved in cancer growth

Oncology -  Escherichia coli genes can be incorporated into colorectal cancer therapy

Oncology - Beta-catenin modulates VEGF expression in colon cancer

Oncology - Carcinoembryonic antigen mRNA marks prospects for colon cancer micrometastasis

Oncology - Cyclooxygenase-2 may contribute to the angiogenesis of gastric cancer

Oncology - Lamivudine staunches chemotherapy-induced hepatitis B virus reactivation

Oncology - The survivin pathway can be pinpointed for angiogenesis suppression in tumors

Oncology - Viral integration at select gene sites preface the advent of cancer

Ovarian Cancer - Completion of R1549 trial expected to happen earlier

Ovarian Cancer - Newly identified serum biomarkers may be key to earlier diagnosis

Ovarian Cancer - Paclitaxel and carboplatin therapy studied in Japanese women

Pediatric Cancer - Role-related meaning scale for pediatric oncology staff is consistent and valid

Pharmacology - Low-toxicity antimalarial drugs wipe out angiogenesis in laboratory assays

Pharmacology - Statins potentiate the anticancer properties of bisphosphonates

Preventive Medicine - More encouragement needed to get cancer screenings

Prognosis - Testing may one day pinpoint which cancer patients are at risk for relapse

Prostate Cancer - Balance of pathways may determine the effect of IL-6 on AR transactivation

Prostate Cancer - Positive results presented with novel antisense drug

Prostate Cancer - Retinoic Acid stimulates radioiodine uptake in gene-transformed cancer cells

Proteomics - HGF receptor upregulation is a significant factor in angiogenic promotion

Proteomics - Human epithelial cell immortalization is a step in carcinogenesis

Pulmonary Medicine - The Wasabia isolate 6-MITC suppresses tumor progression in mice

Renal Cancer - Murine VEGF antibody blocks the growth of human adenocarcinoma

Salivary Duct Carcinoma - Low signal intensity, poor enhancement on MRI may indicate malignancy

Salivary Gland Tumors - Androgen receptors are prevalent in three salivary gland malignancies

Skin Cancer - Atypical fibroxanthoma and malignant fibrous histiocytoma may be a single entity

Soft-Tissue Sarcoma - Careful assessment is required before amputation for soft-tissue sarcoma

Solid Tumors - Analysis of the ATP7B gene and/or protein will help in choosing chemotherapy

Squamous Cancer - Delta-Np63-alpha acts as positive and negative transcriptional regulator

Stem Cell Research - Endothelial progenitor cell tumor homing relies on multiple steps for fruition

Stem Cell Transplantation - Anti-TCRalphabeta monoclonal antibody effective for T-cell ablation in canine model

Stem Cell Transplantation - KIR ligand incompatibility improves survival of unrelated stem cell graft recipients

Stem Cell Transplantation - Postprogenitor cell retransfusion prevents neutropenic fever in stem cell autograft recipients

Tai Chi - Cancer patients find help in ancient martial art

Testicular Cancer - Patients with neurological symptoms may have paraneoplastic syndrome

Testicular Cancer - Testicular cancer can be cured in most patients

Thyroid Cancer - Galectin-3 is involved in the malignant transformation of thyroid cells

Thyroid Cancer - Tc-99m tetrofosmin imaging revealed the lesions better than did the I-131 scan

Transduction - Effective gene delivery to tumors depends on a variety of factors

Transfusion Medicine - Novel culture enables efficient expansion of Valpha24+ T cells

Transfusion Medicine - Unrelated cord blood transplantation effective for advanced myelodysplastic syndrome patients

Women's Health - HIV infection linked to heightened levels of oncogenic HPV in high-grade cervical lesions

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