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Oncology

Cyclooxygenase-2 may contribute to the angiogenesis of gastric cancer

Published in Cancer Weekly, August 12th, 2003

Cyclooxygenase-2 may contribute to the angiogenesis of gastric cancer.

"Angiogenesis is a key prerequisite for the successful establishment, growth, and dissemination of tumors. Vascular endothelial growth factor (VEGF) has a potent angiogenic activity and cyclo-oxygenase-2 (COX-2) promotes angiogenesis by modulated production of angiogenic factors including VEGF. The current study was designed to investigate the possible roles of COX-2 and VEGF in gastric cancer angiogenesis," said scientists in South Korea.

"In this study, we conducted an immunohistochemical investigation of COX-2 and VEGF expression in 97 patients with gastric cancer. To assess...

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