Cancer Weekly

HIV Prevention - Trials of new HIV vaccine begin in U.S., South Africa

HIV/AIDS Cancer - Combined chemotherapy with high-dose methotrexate effective against HIV PEL

Hematology - Bone marrow angiogenesis may promote plasma cell migration in multiple myeloma

Hepatitis - Interferon may prevent hepatocellular carcinoma associated with hepatitis C

Hepatology - Cyclin E is a target for the treatment of liver cancer

Hormone Replacement Therapy - Combination HRT substantially increases breast cancer risk, large study shows

Human Papillomavirus - Few women know about HPV or its link to cervical cancer, study shows

Intracerebral Hematoma - Vasogenic edema 150% of hematoma diameter on MRI may indicate neoplasm

Intracranial Lesions - Stereotactic radiosurgery can be associated with neurotoxicity

Kidney Cancer - Rho factors influence the hypoxia-related pathogenesis of renal cell carcinoma

Legal Issues - Cancer company probes possible accounting irregularities; finance VP resigns

Leukemia - CLL and MM may have different mechanisms of cell survival

Leukemia - Childhood ALL has long-term survival nearing 80%, new treatments still needed

Leukemia - Complete remission of CLL can be associated with Chinese herbal extract

Liver Disease - Imaging tools determine cost-effectiveness for screening transplant candidates

Lung Cancer - Paclitaxel combination improves survival

Lung Carcinoma - p38 Expression is a determinant of apoptotic death induced by aloe-emodin

Lymphoma - FDG-PET has high sensitivity for indolent NHL

Lymphoma Therapy - [F-18]FDG-PET provides valuable information for lymphoma patients undergoing SCT

Macular Degeneration - CA4P suppresses development, induces regression of ocular neovascularization

Malaria Therapy - Genetically modified E. coli may enable high-yield terpenoid production

Malignant Melanoma - Fat-suppressed MRI images show high signal intensity of vaginal melanoma

Medulloblastoma - Study shows retinoids kill childhood brain tumor cells

Mergers and Acquisitions - Dendreon completes acquisition, creates oncology company with enhanced pipeline

Metastasis - Patients survive incurable disease longer with new treatment

Metastasis - Vascular endothelial growth factors associate with colon cancer spread

Metastatic Cancer - Squamous cell carcinoma of larynx can metastasize to ampulla of Vater

Metastatic Melanoma - Hypercalcemia is a risk factor; elevated PTH-rP may be responsible

Mistletoe Immunoactivity - Low-dose mistletoe lectin-1 does not increase TNFalpha and IL-6, high doses do

Myeloma Oncogenesis - Early plasma cell dyscrasia can have IgH rearrangements deregulating cyclin D1

Natural Killer Cells - The ligand binding structure of NK cell receptor NKp44 is dimeric, saddle shape

Nicotine Addiction - Cancer charities launch international tobacco control initiative

Nicotine Addiction - Cigarette pack warnings could get regular makeovers

Nicotine Addiction - Global youth tobacco survey shows no gender difference at half of sites

Nicotine Addiction - UN health agency urges even stronger measures to curb tobacco use

Nicotine Addiction - Vaccine being tested to help smokers

Nicotine Addiction - WHO calls for war on tobacco to include anti-addiction treatment

Non-Hodgkin Lymphoma - Companies announce commercial availability of Bexxar therapeutic regimen

Non-Hodgkin Lymphoma - Incidence of non-Hodgkin lymphoma increasing in Canada

Oncogenes - Scientists demonstrate new method for discovering cancer gene function

Oncogenesis - Surface epithelial inclusion cysts may not be related to ovarian cancer

Oncogenesis - The newly identified gene SVH has been implicated in hepatocellular carcinoma

Oncology - Focal adhesion kinase blockers sensitize breast cancer cells to camptothecins

Oncology - High inducible NOS levels contribute to prostate cancer pathogenesis

Oral Cancer - Brachytherapy is a treatment option for patients with early tongue carcinoma

Osteosarcoma - Researchers characterize genetic markers of pediatric osteosarcoma

Ovarian Cancer - Oral melphalan eliminated for treating platinum-resistant ovarian cancer

Ovarian Cancer - U.S. government funds possible vaccine for ovarian cancer

Pancreatectomy - Pain management among patient needs following pancreatectomy

Pancreatic Adenocarcinoma - DcR3 highly expressed in many pancreatic cancers

Pancreatic Cancer - Multidetector-row CT can be used for preoperative staging of pancreatic cancer

Pancreatic Cancer - Strong alpha6-integrin, weak alpha5beta-integrin independently relate to risk

Pancreatoduodenectomy - Intestinal innervation can be preserved in pancreatoduodenectomy for cancer

Papillomavirus Replication - HPV type 18 appears to use host BRCA-1 for E2-dependent transcription

Patents - Additional U.S. patent granted for prevention of cancer metastasis

Pediatric Brain Tumors - Stereotactic radiosurgery used to treat brain tumors in children

Pediatrics - Danger of pediatric exposure to phthalate plasticizers uncertain

Penile Cancer - Long foreskin and phimosis may explain the high incidence of penile cancer

Prostate Cancer - Core length cannot identify those with clinically insignificant prostate disease

Prostate Cancer - High-grade prostatic intraepithelial neoplasia is a premalignant lesion

Prostate Cancer - Lycopene may be a chemopreventive agent for prostate cancer

Prostate Cancer - Pathology reports contain valuable information for patient management

Prostate Cancer - Prostate specific antigen test has appreciable false positive rate

Prostate Cancer - Researchers propose optimal prostate biopsy scheme

Proteomics - NSD1 essential for early post-implantation development

Public Offering - Oncology company to offer 6 million shares of common stock at $17.00 per share

Pulmonary Disease - Protein alterations occur early in the course of lung cancer progression

Pulmonology - Downregulation of SKP2 causes lung cancer cells to self destruct

Radiation Exposure - Urinary bladder lesions from low-dose radiation from Chernobyl leads to cancer

Radiology - Micro-CT is useful for exploring the architecture of small vessels in tumors

Receptor Deregulation - Loss of ubiquitination may play a significant role in the pathogenesis of cancer

Renal Transplantation - Kidney can be transplanted into an ileocecal reservoir

Scalp Sebaceous Nevus - Malignant melanoma can arise from a sebaceous nevus of the scalp

Secondhand Smoke - Vitamin C helps reduce oxidative stress in passive smokers

Skin Cancer - Scientists close in on new gene

Skin Cancer Management - Guidelines presented for managing primary cutaneous squamous cell carcinoma

Skin Lesions - Seborrheic keratosis can be misdiagnosed as desmoplatic tricholemmoma

Stem Cell Transplantation - HLA-DR11 expression protects against acute GvHD

Stem Cells - Studies identify key genes involved in blood vessel development

Stereotactic Radiosurgery - The role of biological imaging in stereotactic radiosurgery is evolving

Stomach Cancer - The effectiveness of stomach cancer screening in Japan is unknown

Stressed Cell Survival - 2-Aminopurine can inhibit p53 phosphorylation by several pathways

Testicular Cancer - Aneuploidy of germ cell tumors is associated with amplified centrosomes

Testicular Cancer - Retroperitoneal lymphadenectomy and chemotherapy yield good results

Thyroid Carcinoma - Follicular variant of papillary carcinoma has distinct molecular alterations

Urological Tumors - Use of PET for urological tumors is developing

Virology - Combination therapy increases tumor doubling time in cancer models

Virology - PSA promoter-based suicide gene therapy abates benign prostatic hyperplasia

Virology - Vesicular stomatitis virus is oncolytic in hepatocellular carcinoma models

Women's Health - DNAwithPap included in ACOG cervical cancer screening recommendations