Skin Cancer

Fas/FasL signalling apoptosis stops mutations that lead to skin cancer

Published in Cancer Weekly, August 26th, 2003

Apoptosis due to Fas/FasL and other cell death signalling stops mutation accumulation that leads to skin cancer following UV damage.

"Apoptosis plays a critical role in the development and progression of ultraviolet-induced skin cancers. In particular, Fas and Fas ligand (FasL) interactions are known to control the development of sunburn cells or apoptotic keratinocytes in the UV-exposed epidermis. In the absence of functional Fas/FasL signaling, UV-induced apoptosis is diminished and mutations rapidly accumulate," investigators in the United States report.

"UV-induced suppression of host immunity, a process regulating skin cancer outgrowth, is also...

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Source: Cancer Weekly (2003-08-26)

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