Proteomics
The true bioactive conformation of anginex is the beta sheet
Published in Cancer Weekly, September 2nd, 2003
"Anginex is a designed peptide 33mer that functions as a cytokine-like agent to inhibit angiogenesis. Although this short linear peptide has been shown by NMR and CD to form a nascent beta-sheet conformation in solution, the actual bioactive structure formed upon binding to its receptor on the surface of endothelial cells could be quite different," according to scientists in the United States.
"By using a series of double-cysteine disulphide-bridged analogues, we provide evidence in the present study that the beta sheet is in fact the bioactive conformation of anginex," stated...
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Source: Cancer Weekly (2003-09-02)
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