Oncology
COX-2 causes prostaglandin E2 to modulate pancreatic cancer angiogenesis
Published in Cancer Weekly, September 2nd, 2003
"In some cancers cyclooxygenase (COX) inhibition appears to be anti-mitogenic and anti-angiogenic, but the actions of COX-derived prostaglandins in pancreatic cancer (PaCa) are unknown. In this study COX-2 was detected in three of six PaCa cell lines while COX-1 was identified in all cell lines. COX-2 expression correlated with basal and arachidonic acid (AA) stimulated prostaglandin E2 (PGE(2)) production," wrote G. Eibl and colleagues, University California Los Angeles, David Geffen School of Medicine.
"PGE(2) production was inhibited by the COX-2 inhibitor nimesulide. In...
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Source: Cancer Weekly (2003-09-02)
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