Cervical Cancer
Papillomavirus E7 protein blocks pCAF's acetyltransferase, a p53 coactivator
Published in Cancer Weekly, September 2nd, 2003
According to a study from Canada, "Most cervical carcinomas express the E6 and E7 proteins of a high-risk human papillomavirus (HPV). These proteins affect growth control by interfering with the functions of cell regulatory proteins, promoting oncogenic transformation.
"A key target of E7 is the tumor suppressor protein pRb, which directly interacts with E7. However, binding to additional cellular regulatory proteins is clearly required for oncogenesis, as mutants of E7 have been identified that bind to pRb, yet fail to...
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Source: Cancer Weekly (2003-09-02)
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