Published in Cancer Weekly, September 2nd, 2003
"The heterogeneous nature of the mutations, the size, and the complexity of the factor VIII gene makes direct mutation analysis in hemophilia A families in India an option that is not very feasible and practical," scientists in New Delhi explained. "Thus, carrier screening and prenatal diagnosis of hemophilia A often depends on haplotype analysis using restriction fragment length polymorphisms (RFLP) and short tandem repeat (STR) markers to track the defective factor VIII gene within a family."
M.R. Chowdhury and colleagues at the All India Institute of Medical Sciences...
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