Prostate Cancer

Targeting the EGFR function inhibits not only tumor growth but also invasiveness

Published in Cancer Weekly, September 9th, 2003

Targeting the EGFR function inhibits not only tumor growth but also invasiveness.

According to recent research published in the International Journal of Biological Markers, "Increased urokinase plasminogen activator (uPA) levels and epidermal growth factor receptor (EGFR)-related tyrosine kinase activity are associated with poor prognosis in several cancers.

"We studied the effect of epidermal growth factor (EGF) and a specific inhibitor of EGFR, ZM252868, on the growth and invasiveness of the prostate cancer cell lines PC3 and DU145," wrote A. Unlu and colleagues, Mersin University.

"PC3 cell growth was stimulated by...

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Source: Cancer Weekly (2003-09-09)

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