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HIV/AIDS Cancer

CD28 and ligands involved in AIDS- and EBV-associated lymphoma development

Published in Cancer Weekly, September 9th, 2003

The CD28 molecule appears to play a key role in the development of AIDS- and EBV-associated lymphoma.

According to recent research from the United States, "CD28, which is expressed on most T cells, can provide a costimulatory signal during T cell activation."

"Although principally considered to be a T cell-associated molecule, CD28 has been seen to be expressed on mast cells and natural killer cells, as well as on plasma and myeloma cells, but not on cells representing earlier stages of B cell development," explained D. Widney and colleagues at the University of California-Los Angeles.

In their study, the investigators found that...

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