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Oncology

Cavtratin blocks vessel permeability to suppress tumor progression in mice

Published in Cancer Weekly, September 16th, 2003

Cavtratin blocks vessel permeability to suppress tumor progression in mice.

"Tumor vasculature is hyperpermeable to macromolecules compared to normal vasculature; however, the relationship between tumor hyperpermeability and tumor progression is poorly understood. Here we show that a cell-permeable peptide derived from caveolin-1, termed cavtratin, reduces microvascular hyperpermeability and delays tumor progression in mice," scientists in the United States report.

"These antipermeability and antitumor actions of cavtratin occur in the absence of direct cytostatic or antiangiogenic effects. Cavtratin blocks microvascular permeability by inhibiting...

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