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Breast Cancer

Elevated DNA damage is significantly associated with breast cancer risk

Published in Cancer Weekly, September 16th, 2003

Elevated DNA damage is significantly associated with breast cancer risk.

"To evaluate whether deficient DNA repair contributes to elevated DNA damage and breast carcinogenesis, we used the comet assay (single-cell alkaline gel electrophoresis) to measure the levels of DNA damage in peripheral lymphocytes from 70 breast cancer cases and 70 controls," scientists in the United States report.

"DNA damage, measured as the comet tail moment, was not influenced by age, family history (FH), age at menarche, age at first birth or parity. The results showed that cancer cases had significantly higher DNA damage compared with controls," wrote T.R. Smith and...

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