Cell-Cycle Regulation
Disabled-2 is phosphorylated by cdc2 and dephosphorylated by Pir1
Published in Cancer Weekly, September 16th, 2003
"Disabled-2 (Dab2; also known as p96 and DOC-2) is a signal transduction protein that has been implicated in the control of cell growth. Dab2 is known to be a phosphoprotein, but little is known about the kinases that phosphorylate Dab2. We have found that Dab2 phosphorylation is markedly increased during the mitosis phase of the cell cycle," scientists in the United States report.
"This phosphorylation is blocked by roscovitine, a selective inhibitor of cyclin-dependent kinases....
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Source: Cancer Weekly (2003-09-16)
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