Published in Cancer Weekly, September 16th, 2003
According to recent research from the United States, "An increasing number of model systems of plasma cell tumor (PCT) formation have been and are being developed. Discussed here are six models in mice and multiple myeloma (MM) in humans. Each model illustrates a unique set of biological factors.
"There are two general types of model systems: those that depend upon naturally arising mutagenic changes (pristane-induced PCTs, 5TMM, and MM) and those that are associated with oncogenes (Emu-v-abl), growth factors (IL-6), and anti-apoptotic factors (Bcl-x(L)/Bcl-2). PCTs develop in...
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