Human Papillomavirus
Alterations of the HPV-16 E5 gene increases expression, lowers cell lifespan
Published in Cancer Weekly, September 16th, 2003
According to a study from the United States, "The human papillomavirus type 16 (HPV-16) E5 protein is an 83 amino-acid (aa), hydrophobic polypeptide that has been localized to intracellular membranes when overexpressed in COS-1 cells. While the HPV-16 E5 protein appears to modulate endosomal pH and signal transduction pathways, genetic analysis of its biological activities has been hampered by low (usually undetectable) levels of expression in stable cell lines.
"Sequence analysis of the native HPV-16 E5 gene revealed that infrequent-use codons are...
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Source: Cancer Weekly (2003-09-16)
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