Cancer Weekly

Cancer Vaccine - Peptide-based vaccine effective against myelodysplastic syndrome

Metastasis - Cancer biologists and a cardiologist take a new look at aggressive tumors

Antitumor Therapy - TRAIL is an inducer of tissue injury in humans

Breast Cancer - Computer analysis of shadows on breast ultrasound improves lesion detection

Breast Cancer - Different pattern of metastatic spread observed in BRCA1 and BRCA2 carriers

Cancer Pathogenesis - Transcription factor Egr-1 is a foundation for angiogenesis during tumor growth

Ethics - Early foundations of medicine help physicians face modern challenges

Advanced Solid Cancer - BAK therapy shows life-prolonging effect without adverse effects

Antioxidant Tea - Patent issued for producing black tea rich in theaflavins

Antitumor Drugs - ONO-4007 kills tumor by restoring Th1 cytokines, macrophage NO production

Apoptosis - Interferons alpha and beta boost p53 activity against cancer, viruses

Autoimmune Disease - New finding sheds light on mechanism of inflammation in lupus, other disorders

Autoimmunity - Giant congenital melanocytic nevus has a nonmalignant, hypopigmented variant

Basal Cell Cancer - Nuclear morphometry could not distinguish between primary and recurring tumors

Benign Lymph Tumor - Sphenoid sinus lymphangioma is an extremely rare benign lymph tumor

Biomanufacturing - Company will introduce aprotinin for research in 2004

Bladder Cancer - Hepatoma-up-regulated protein is higher in patients with recurrent cancer

Bladder Cancer - Several genes for bladder cancer progression discovered using cDNA microarrays

Brain Proteins - Steroidogenic acute regulatory protein expression is higher in brain tumors

Breast Cancer - Amooranin induces apoptosis via caspase activity in breast cancer cell lines

Breast Cancer - BAG-1 prevents stress-induced long-term growth inhibition in breast cancer cells

Breast Cancer - Prospective multicenter study for quality management evaluated

Cancer Detection - Measurement of DNA integrity may detect cancer

Cancer Diagnostics - DakoCytomation partnership develops new tools for prostate cancer diagnostics

Cancer Genomics and Genetics - "Dual switch" mechanism identifed in met oncogene

Cancer Pain - PAINConsultN may be effective answer to cancer pain management barriers

Cancer Patients - Patient-physician interaction assumes great significance in cancer care

Cancer Physiology - Canine tumors demonstrate interrelatedness between angiogenesis and mast cells

Cancer Research - Gene needed for antibody-producing cell development is key to blood cell cancer

Cancer Therapy - Kringle fragments of human apolipoprotein(A) block angiogenesis and cancer

Cancer Therapy - Lutetium-177 launched

Cancer Therapy - Multimodal treatment of adrenocortical cancer effective

Cancer Therapy - Multiplex long QPCR suitable for measuring gene-specific treatment damage and repair efficacy

Cancer Therapy - Study finds potential way to improve cancer immunotherapy

Cancer Vaccine - Dendritic cell vaccines showing promise for treatment of brain tumors

Celiac Disease - Systemic reaction to gluten involving T cells can lead to other diseases

Cell Biology - Cells' ability to live without oxygen gives clues for treating major diseases

Cell Biology - Researchers try to determine why cancer cells don't commit suicide

Cell Proliferation - Aspirin, indomethacin inhibit T98G glioblastoma growth, induce apoptosis

Cervical Cancer - Micronuclei are elevated in uterine smears of cervix cancer patients

Chronic Myeloid Leukemia - NICE recommends first line treatment with Glivec for new CLE patients

Collaborations - Research alliance with 3-Dimensional Pharmaceuticals terminated

Colon Cancer - Mutations in the candidate tumor suppressor gene FLJ12973 are rare

Colon Cancer - SEREX analysis yields KY-CC-3/COX1 as a possible colon cancer antigen

Colon Cancer - SLC5A8 is a tumor suppressor gene silenced by methylation

Colorectal Cancer - Patterns of expression of cyclin D I may provide abnormal cell biomarkers

Colorectal Cancer - Physical activity lowers risk of colorectal cancer

Colorectal Cancer - Self-reported colorectal cancer screening compared with medical records

Compound Librarires - New compound library to speed drug discovery

Congenital Rhabdomyosarcoma - Neonatal congenital rhabdomyosarcoma is treatable with surgery, chemotherapy

DNA Repair - Noxa gene does not appear to be a determinant in colorectal cancer

Dermatology - Epithelioid hemangioendothelioma may metastasize after excision

Diagnostics - FDA clears Aurora Self-Expanding Biliary Stent System

Diagnostics - Serum granulysin may make a good marker for cell-mediated immune status

Doppler Sonography - There are changes in signal area after administration of signal-enhancing agent

Drug Development - Innovations in oligonucleotide drug delivery reported

Drug Development - Novel Psychotria extracts show antiparasitic and anticancer activity

Environmental Monitoring - The BTEX ELISA kit works well to detect petroleum products in groundwater

Enzymology - Timing is key to gene-directed therapy and cancer cell sensitivity

Finance - $35M private financing completed by pharmaceutical company

Finance - Genetic-focused company reports record revenues for fiscal 2003

Finance - Oncology company to receive $16.8M in connection with cancer vaccine alliance

GI Cancer - Poorly differentiated endocrine carcinoma can have giant, not just small cells

Gastroenterology - The new matrix metalloproteinase inhibitor TN-6b fights cancer spread

Gene Therapy - Geron wins patent for human telomerase promoter, triggers payment

Genetic Disorders - HSV vectors may be useful for ataxia-telangiectasia gene therapy

Genomics - NaPro to sell worldwide generic paclitaxel business

Gynecologic Cancers - Foundation urges women to take four preventive steps

Gynecology - Angiostatin correlates with a favorable prognosis for women with ovarian cancer

Gynecology - Ovarian cancer cells generate angiogenic factors at high levels

HIV/AIDS - Risk factors for high-risk HPV infection identified for HIV patients

Hairy Cell Leukemia - Rituximab has only modest single-agent activity against HCL in a Phase 2 study

Head and Neck Cancer - Cyclooxygenase-2 associates with VEGF expression in squamous cell carcinomas

Hematologic Malignancy - p16(INK4A) and p14(ARF) is often overexpressed in hematological malignancies

Hematology - Bone marrow stem cells conduct the vasculogenesis of solid tumor growth

Hematopoietic Stem Cells - Osiris Therapeutics awards mesenchymal stem-cell technology rights in Japan

Hepatocellular Carcinoma - Seocalcitol may be effective in inoperable hepatocellular cancer

Human Papillomavirus - HPV status may help identify prognosis of cervical lesions

Imaging - Phase I of breast cancer detection study yields positive results

Immune Enhancers/Stabilizers - Myelopeptides are immunostabilizers, antibody inducers, anticancer effectors

Immunology - Company announces its most significant anticancer patent application to date

Immunology - New patent broadens company's JNK intellectual property estate

Immunology - Recognition of CpG motifs expressed by oligodeoxynucleotides

Leukemia - Functional markers could be helpful to predict clinical behavior of ALL

Leukemia - Hospitals identify ways to improve treatment of childhood leukemia in Honduras

Leukemia - Mitochondrial-targeted fatty acid analog induces apoptosis

Leukemia - Several ETS genes may play key roles in hematopoietic differentiation

Leukemia - Survival of acute myeloid leukemia cells requires PI3 kinase activation

Leukemia Genetics - A new HMGA2 locus rearrangement is found in acute lymphoblastic leukemia