Apoptosis
Interferons alpha and beta boost p53 activity against cancer, viruses
Published in Cancer Weekly, September 23rd, 2003
"Swift elimination of undesirable cells is an important feature in tumor suppression and immunity. Tumor suppressor p53 and interferon-alpha and beta (IFN-alpha/beta) are essential for the induction of apoptosis in cancerous cells and antiviral immune responses, respectively, but little is known about their relationship," scientists in Japan report.
"Here we show that transcription of the p53 gene is induced by IFN-alpha/beta, accompanied by an increase in p53 protein level. IFN-alpha/beta signaling itself does not activate p53; rather, it contributes...
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Source: Cancer Weekly (2003-09-23)
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