Oncology
Drosophila protein diminishes prostate cancer cell survival
Published in Cancer Weekly, September 23rd, 2003
"The effects of expression of Drosophila melanogaster Ca2+ permeable transient receptor potential-like (TRPL) channels, under the control of the cytomegalovirus (CMV) or prostate cell-specific promoters, on cell survival and apoptosis in the androgen-sensitive LNCaP prostate cancer cell line were investigated. A prostate-specific antigen (PSA) promoter construct (designated PSAEn/PSAPr) composed of a 0.6 kb region of the promoter and a 1.45 kb region of the enhancer resulted in androgen-dependent and prostate-specific expression of a luciferase reporter gene in transiently transfected LNCaP...
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Source: Cancer Weekly (2003-09-23)
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