Cancer Detection
Measurement of DNA integrity may detect cancer
Published in Cancer Weekly, September 23rd, 2003
According to a study from the United States, "Tumor-released DNA in blood represents a promising biomarker for cancer detection. It has been postulated that tumor necrosis causes release of DNA of varying sizes, which contrasts apoptosis in normal tissue that releases smaller and more uniform DNA fragments.
"To test the hypothesis that increased DNA integrity, i.e., a longer DNA strand, is a tumor-associated marker in plasma, we determined the genomic DNA integrity index in plasma DNA using real-time PCR assays. A DNA integrity index and DNA concentration in plasma were determined in 61 patients with...
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Source: Cancer Weekly (2003-09-23)
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