Cancer Pathogenesis
Transcription factor Egr-1 is a foundation for angiogenesis during tumor growth
Published in Cancer Weekly, September 23rd, 2003
"Current understanding of key transcription factors regulating angiogenesis is limited. Here we show that RNA-cleaving phosphodiester- linked DNA-based enzymes (DNAzymes), targeting a specific motif in the 5 untranslated region of early growth response (Egr-1) mRNA, inhibit Egr-1 protein expression, microvascular endothelial cell replication and migration, and microtubule network formation on basement membrane matrices," scientists in Australia report.
"Egr-1 DNAzymes blocked angiogenesis in subcutaneous Matrigel plugs in mice, an observation that was independently...
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Source: Cancer Weekly (2003-09-23)
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