Hematologic Malignancy
p16(INK4A) and p14(ARF) is often overexpressed in hematological malignancies
Published in Cancer Weekly, September 23rd, 2003
According to recent research from South Korea, "Two proteins, p16(INK4A) and p14(ARF), originating from the same gene locus CDKN2A , use different promoters and alternative reading frames.
"p16(INK4A) is translated from alpha transcript and p14(ARF) is from beta transcript. These two proteins, which are inactivated in some human malignancies, are possible tumor suppressor candidates," wrote Y.K. Lee and colleagues, Hallym University, College of Medicine.
"In this study, we investigated the expression of p16(INK4A) and p14(ARF) mRNAs in hematological...
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Source: Cancer Weekly (2003-09-23)
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