Leukemia Genetics
A new HMGA2 locus rearrangement is found in acute lymphoblastic leukemia
Published in Cancer Weekly, September 23rd, 2003
According to a study from Italy, "We report the first case of acute lymphoblastic leukemia associated with a t(9;12)(p22;q14) translocation within the HMGA2 locus.
"The breakpoint lies in the 5' region. Fluorescence in situ hybridization with a BAC clone covering the 5' region produced 3 signals versus 2 signals with a BAC clone covering the 3' region including intron 3 of HMGA2, which harbors most of the breakpoints described in benign mesenchymal tumors. HMGA2 locus rearrangement was associated with overexpression of an HMGA2 mRNA that lacked a carboxy-terminal tail," wrote...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
Source: Cancer Weekly (2003-09-23)
More Articles from Cancer Weekly
- Cancer Vaccine
Peptide-based vaccine effective against myelodysplastic syndrome - Metastasis
Cancer biologists and a cardiologist take a new look at aggressive tumors - Antitumor Therapy
TRAIL is an inducer of tissue injury in humans - Breast Cancer
Computer analysis of shadows on breast ultrasound improves lesion detection - Breast Cancer
Different pattern of metastatic spread observed in BRCA1 and BRCA2 carriers - Cancer Pathogenesis
Transcription factor Egr-1 is a foundation for angiogenesis during tumor growth - More from this issue of Cancer Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
