Metastasis

Cell suffocation may cause cancer spread

Published in Cancer Weekly, September 30th, 2003

Starving tumor cells of oxygen may trigger their spread to other bodily organs. Low oxygen activates a gene called CXCR4, which causes cancerous cells to metastasize, new research shows.

The results edge us closer to an understanding of the timing of tumor progression. Wilhelm Krek and colleagues added a gene - known as pVHL - to renal carcinoma cells. The gene is normally present under conditions of low oxygen, but is absent in many tumors. They then looked for changes in the activity of thousands of other genes, and found that pVHL caused a dramatic reduction in the production of a receptor protein called CXCR4. This receptor allows migrating cancer cells to spread to...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Cancer Weekly

Source: Cancer Weekly (2003-09-30)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry