Published in Cancer Weekly, September 30th, 2003
The results edge us closer to an understanding of the timing of tumor progression. Wilhelm Krek and colleagues added a gene - known as pVHL - to renal carcinoma cells. The gene is normally present under conditions of low oxygen, but is absent in many tumors. They then looked for changes in the activity of thousands of other genes, and found that pVHL caused a dramatic reduction in the production of a receptor protein called CXCR4. This receptor allows migrating cancer cells to spread to...
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