Cancer Weekly

Hepatology - Normal and tumor human and murine liver NKT cells are dissimilar

Hepatoma - PEITC potently induces apoptosis and cell-cycle arrest in HepG2 cells

Herpesvirus - KSHV transcription factor K-bZIP prolongs cell cycle transition in infected cells

Hodgkin Disease - Routine CT scan is of little value in following patients with Hodgkin's disease

Human Neoplasms - Oncogenic transformation by BK virus may lead to human tumors

Immunology - Antiangiogenic mechanisms may be responsible for interleukin-12 tumor control

Immunology - Corixa Corp. signs research, development, and license agreement

Immunology - New patent broadens company's JNK intellectual property estate

Immunology - Two phase II clinical trials for Vitaxin begin

Information Technology - Grant to be used to study technology for cancer treatment

Laparoscopic Surgery - Data lacking on venous thromboembolism prophylaxis

Legal Issues - Patent issued covering cremophor-free taxanes

Letter to the Editor - Phthalates and children

Leukemia - Anthocyanidins induce apoptosis in human promyelocytic leukemia cells

Leukemia - Grants fund research on leukemia, lymphoma, and myeloma treatments

Leukemia - p15 Methylation has a poor prognostic impact on disease-free survival

Leukemia Therapy - High-dose hydroxyurea shows promise for treatment of high-risk AML patients

Liver Cancer - Laser therapy offers alternative to surgery for liver tumors

Lung Cancer - $464,000 Grant given to conduct research on lung cancer immunotherapy

Lung Cancer - COX-2 inhibitors might improve the efficacy of cancer radiation therapy

Lung Cancer - Combined CPT-11 and ifosfamide is effective in relapsed SCLC

Lung Cancer - Loss of PDCD4 expression correlates with tumor progression and prognosis

Lung Cancer - Low levels of chromium(VI) selectively activates Src family kinases, JNK

Lung Cancer - Lung cancer vaccines yield promising results in clinical trials

Lung Cancer - Tc-99m-MIBI scintigraphy might be valuable in detecting recurrent lung cancer

Lung Cancer - Ultrasound-guided endoscopy may have role in evaluation of mediastinal lesions

Lung Cancer - Vitamin K2 may be used for lung cancer therapy

Lymphoma - Mutation of the BIK gene is a frequent feature of B-cell lymphomas

Lymphoma Therapy - Telomere shortening seen after chemotherapy in NHL patients

Malignant Glioma - Oncolytic adenovirus may accelerate radiation-induced tumor fibrosis

Mast-Cell Disease - Imatinib may inhibit the growth-promoting role of wild-type ckit

Melanoma - Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo

Melanoma - Knowledge of genetics has generated optimism for prevention program development

Melanoma - Phase II study demonstrates vaccine effectiveness in half of patients

Melanoma - Positive results reported in phase III trial of Genasense plus chemotherapy

Melanoma - Systemic treatment for advanced melanoma reviewed

Melanoma - Two clinical milestones achieved for Vitaxin

Meningioma - Brain neoplasms with a malignant phenotype express higher levels of COX-2

Mergers and Acquisitions - Acquisition offers company methods to fight bioterrorism

Mergers and Acquisitions - Genzyme completes tender offer

Mesothelioma - Wnt signaling plays a role in the pathogenesis of mesothelioma

Myeloma - Researchers find genetic variations may predict treatment responses

Myocardial Ischemia - Hypoxia-inducible VEGF gene delivery may treat ischemic heart disease

Necrosis Factor Receptor - TRAF2 controls cell sensitivity to apoptosis

Neuroimmunology - Many paraneoplastic neurologic syndromes may be immune mediated

Non-Hodgkin Lymphoma - Medicare coding instructions issued for Bexxar

Oligodendrogliomas - Cyclins other than D1 are expressed in higher grade oligodendrogliomas

Oncogene - P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein

Oncogenesis - Human prostate cancers lack evidence of KLF6 tumor suppressor gene mutations

Oncogenesis - Powerful new method helps reveal genetic basis of cancer

Oncogenesis - Survivin is expressed in premalignant lesions, more in oral squamous cancers

Oncology - Lutein blocks murine tumor growth through antiangiogenesis and apoptosis

Oncology - Tumor-specific gene therapy diminishes thyroid cancers without adverse effects

Oncology Research - Grant to help fund cancer research

Oral Mucositis - Study demonstrates CG53135's activity in two animal models

Ovarian Cancer - Immunotherapeutic approaches in ovarian cancer reviewed

Ovarian Cancer - New phase of Northern Ireland screening trial launched

Ovarian Cancer - Paclitaxel temporarily adds to the sensory neurotoxicity of cisplatin

Ovarian Cancer - Royalty rights to R1549 obtained by U.K. biotech company

Ovarian Tumors - Tumors of the gonadal stroma are potentially malignant

Pancreatic Cancer - FDA gives orphan drug approval to REXIN-G

Pancreatic Cancer - Link found to developmental cell signaling pathway

Pancreatic Cancer - Obesity increases risk of pancreatic cancer

Pancreatic and Prostate Cancer - Financing secured for the development of cancer vaccines

Pediatric Leukemia - Clofarabine gets fast track designation

Personnel - Canadian biopharma announces new board members

Personnel - Drug discovery company names John A. Keller executive VP, chief business officer

Personnel - Michael R. Dougherty steps down from board of directors

Personnel - Zelefsky named to board of directors at pharmaceutical firm

Prostate Cancer - Bombesin may act as a mitogen in prostate cancer

Prostate Cancer - Brachytherapy seed supplier now sells direct

Prostate Cancer - Cdc37 is necessary for normal human prostate epithelial cell survival

Prostate Cancer - GST genotype not linked to increased prostate cancer risk, but may have protective effect

Prostate Cancer - Grape seed extract may be an effective therapeutic agent for prostate cancer

Prostate Cancer - Promising results reported on new protease activated therapy

Prostate Cancer - U19 suppresses prostate tumor growth

Prostate Cancer Markers - Oncofetal protein p65 may be useful added marker in prostate cancer

Proteomics - PDE2 and PDE4 inhibitors reduce VEGF-inspired cell growth and migration

Pseudomyxoma Peritonei - Pseudomyxoma peritonei is reviewed

Radiology - Math tool promises to cut dose calculation time

Rectal Cancer - Endosonograpy and MRI are important in staging rectal cancer

Reimbursement - Companies offer additional reimbursement coverage for capsule endoscopy

Renal Transplantation - A transplanted kidney can be interpreted as a malignant lesion on FDG PET

Research Funding - Devices could help diagnose precursors to cancer

Sexually Transmitted Disease - Virus-associated growths might be prevented with sexual education

Skin Cancer - Two UN agencies and partners launch campaign to prevent overexposure to sun

Skin Infections - Cutaneous T-cell lymphoma patients do not show association with Chlamydia

Stem-Cell Research - VEGF disruption affects tumors derived from stem cells and oncogenes differently

Stem-Cell Transplantation - Erythropoietin reduces transfusion needs during aggressive lymphoma treatment

Stem-Cell Transplantation - Granisetron effective as antiemitic for bone marrow transplant recipients

Stents - European surgeons implant new nonvascular stents

Stock Market - IMPATH announces commencement of formal SEC investigation

Systemic Lupus Erythematosus - Lupus can affect children with sickle cell disease

Thromboembolism - Many British oncologists unaware of cancer clot risk

Thrombosis - Central line thrombosis in patients with cancer is a common complication

Thyroid Cancer - Radioiodine improves prognosis for patients with pulmonary metastases

Thyroid Disease - VEGF-C overexpression is detected in papillary thyroid cancer

Tongue Cancer - Tumor thickness predicts cervical nodal metastases and survival in early disease

Transfusion Medicine - Blood platelets may last longer on shelf

Tumor Histology - Noninvasive bladder cancer has microinvasion; may affect recurrence, progression

Tumor Metastasis - Use of in vivo radiolabelled cytokines can help locate inflammation, metastasis

Tumor Response - SPET and PET have a role in monitoring tumor response to therapy

Tumor Suppression - SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability Smad4

Urology - PTEN gene therapy suppresses tumor growth and sensitizes cells to doxorubicin

Vascular Endothelial Growth Factor - Partnership to develop, commercialize the VEGF Trap

Vector Development - External controllers would improve the efficacy of cancer gene therapy

Venous Thromboembolism - Low-molecular-weight heparins are safe and effective for cancer patients

Vesnarinone - Analysis of differentiation therapy might provide targeted molecules for therapy