Antisense p21 ODN triggers breast cancer cell apoptosis

"Whereas 40% of human breast carcinomas harbor mutations in the tumor suppressor protein p53, the use of tests demonstrating the presence of p53 mutations as a prognostic marker in breast cancer has not altered clinical management," scientists in the United States explained. "Therefore, the search for new markers, especially among cell cycle-regulatory molecules, is a high priority, both in terms of prognostication and for identification of novel targets."

The protein "p21 regulates the outcome of the p53 response to DNA damage, as might occur after administration of a chemotherapeutic...

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