Oncogenesis

Better model of cancer development sheds light on potential angiogenesis target

Published in Cancer Weekly, November 11th, 2003

Johns Hopkins Kimmel Cancer Center researchers have learned that a common, cancer-linked gene thought to control blood vessel growth may not turn out to be useful as an effective target for cancer drug development.

Their research, published in Cancer Cell, found that results of previous studies that pinned hope on the Id1 gene may not hold up in a mouse model thought to more accurately represent how humans get cancer.

The scientists began their study attempting to confirm previous work, including their own, suggesting that Id1 activation was an important step in tumor angiogenesis, a process that builds blood vessels needed for tumor...

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Source: Cancer Weekly (2003-11-11)

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