Susan Hasty, Publisher
Table of Contents . . . November 18th, 2003
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Cancer Risk Factors - Intraepithelial neoplasia may be leading risk factor for prostate cancer
Metastasis - Stem cells shed light on cancer's spread
Cancer Therapy - Cancer cell telomerase inhibition doesn't compromise chemotherapy
Intestinal Lymphoma - Free perforation can occur in intestinal lymphoma and celiac disease
Prostate Cancer - Dose of PTEN protein found to determine progression of disease
Prostate Cancer - Vector carrying diphtheria toxin A diminishes cancer lesions
AIDS Vaccine - New $16.8M NIH award supports development of vaccine
Alternative Medicine - Ginger curbs tumor growth in mice
Anemia Therapy - Darbepoetin alfa is novel erythropoiesis-stimulating protein
Anticancer Agents - Bisdioxopiperazines target ATP-bound topoisomerase II
Anticancer Therapy - Rigorous trials of mistletoe extracts fail to demonstrate efficacy of therapy
Anticancer Therapy - SMF and anti-neoplastic chemotherapy appear safe together
Barrett Carcinoma - Jejunal interposition after distal esophageal resection shows good function
Barrett Esophagus - Barrett esophagus is excellent model to study early neoplastic progression
Bladder Cancer - Bladder cancer detected by high-volume molecular analysis of urine sediment
Bladder Cancer - Proteomics-based test available in U.S. for diagnosis of bladder cancer
Breast Cancer - A neural survival factor is a candidate oncogene in breast cancer
Breast Cancer - Abraxane data to be presented at San Antonio Breast Cancer Conference
Breast Cancer - Alcohol use boosts risk of hormonally sensitive breast cancers in older women
Breast Cancer - An RNA molecule functions as a tumor suppressor in human breast cancer
Breast Cancer - BRC repeat, RAD51 sequence conservation shows import of BRCA2-RAD51 interactions
Breast Cancer - BRCA1 might function as a molecular scaffold for p53 response
Breast Cancer - Fewer than half of senior women receive radiation therapy after lumpectomy
Breast Cancer - Gene expression analyzed in as few as 100 breast cells from high-risk women
Breast Cancer - Genetic polymorphisms in ER-alpha gene may play role in breast cancer etiology
Breast Cancer - Genetics company identifies novel genetic risk markers for breast cancer
Breast Cancer - Guidelines offer basis for timely mortality reduction of breast cancer
Breast Cancer - High levels of saturated fat, meat intake may slightly increase disease risk
Breast Cancer - Human breast tumors aberrantly express lipoxygenases and cyclooxygenase-2
Breast Cancer - Region-based wavelet coding methods improve the utility of digital mammography
Breast Cancer - Short trinucleotide repeat genotypes of AR gene protect against breast cancer
Breast Cancer - Smokers with breast cancer twice as likely to die than non-smoking patients
Breast Cancer - Study says HRT should be discontinued at diagnosis of breast cancer
Breast Cancer - Tamoxifen can induce, support changes that lead to altered ERalpha expression
Breast Cancer - Tc99m-HMPAO encapsulating VIP-SSL can be used for imaging breast cancer
Breast Cancer - Topotecan may be promising therapy for recurrent disease
Breast Cancer - Two companies collaborating on breast cancer vaccine
Breast Cancer Incidence - Traditional Japanese dietary factors may protect against breast cancer
Breast Cancer Model - Mitoxantrone-loaded microspheres for intratumoral chemotherapy improved survival
Breast Cancer Screening - California mammography rates show regional and ethnic disparities
Breast Cancer and Fertility - Cancer organizations partner to address fertility
Cancer Care Funding - Senators and cancer community leaders fight proposed cancer care cuts
Cancer Detection - French hospital begins clinical evaluation of RECAF cancer detection kits
Cancer Diagnostics - Scientists test protein as early cancer detection agent
Cancer Metastasis - Tie-1 monoclonal antibodies detect angiogenesis in metastatic cancers
Cancer Prevention - Nutrition's role in cancer prevention still needs more study
Cancer Prevention - Pomegranate fruit extract is a novel agent against skin cancer in mice
Cancer Prevention - Research finds tumor preventive qualities, damage reversal, in green tea
Cancer Research - Hutchinson Cancer Center to explore use of nanotechnology tools
Cancer Research - IBC Pharmaceuticals enters research collaboration with Schering, AG
Cancer Risk - Understanding lifestyle changes may provide new insight in cancer prevention
Cancer Therapy - Anti-mouse VEGFR2 antibodies are useful for vascular targeting and imaging
Cancer Therapy - Company publishes results of studies on the mechanism of action of Virulizin
Cancer Therapy - Immunotherapy and antiangiogenic therapy combine to reject tumors
Cancer Therapy - Results of phase I clinical trial of GCS-100 announced
Cancer Treatment - FDA grants Fast Track Designation for HCC treatment
Cancer Treatments - Taiwan-based companies jointly develop novel cancer treatment
Cancer Vaccine - Clinical application of dendritic cells in cancer vaccines reviewed
Cancer Vaccine - Dendritic cell vaccine generates anti-B16BL6 melanoma immunity in mice
Cancer Vaccine - GMCSF gene modified tumor vaccine shows promise in advanced lung cancer
Cancer Vaccine - Individualized human scFv vaccines produced in plants
Cancer-induced Retinopathy - Antirecoverin antibodies in response to tumor don't guarantee retinopathy
Carcinogens - Ionizing radiation induces heritable disruption of epithelial cell interactions
Cardiology - The depictions of tumor vessel physiology on MRI should not be misconstrued
Cardiomyopathy - Cardiac mitochondria may be key in doxorubicin-induced cardiac failure
Cervical Cancer - Cancer center offers DNAwithPap Test for adjunctive cervical screening
Cervical Cancer - Final guidance issued on use of liquid-based cytology in U.K.
Cervical Cancer - Pap smear discrepancies suggest the need for better sample evaluation
Cigarette Smoke - EHC produces a much different smoke from standard cigarette
Cisplatin - Apoptosis markers show there can be cochlear damage from cisplatin
Collaborations - Alliance to offer portable radiation oncology system
Collaborations - Research alliance with Merck targets
Colon Cancer - BRAF mutations are not a consequence of defective mismatch repair per se
Colon Cancer - CDX2 upregulates transcription of the p21/WAF1/CIP1 gene
Colon Cancer - Lymph node staging guidelines of sigmoid, rectum adenocarcinoma evaluated
Colon Cancer - Overexpression of the beta-catenin binding domain of Cad5CD kills HT29 cells
Colon Cancer - TR3 translocation may initiate apoptotic cascade in colon cancer cells
Colorectal Carcinoma - Unique CIs were present in a subset of MSI-H colorectal carcinomas
DNA Damage - Prkdc does not seem to be susceptibility factor for acute benzene toxicity
Dermatology - Photodynamic therapy helps acne, rosacea, sun damage
Diagnostics - 510k clearance granted for patient positioning technology
Diagnostics - Burning mouth syndrome does not appear to be indicative of underlying cancer
Disease Prevention - Four servings daily of fruits, veggies can halve women's breast cancer risk
Disease Prevention - Healthy living may be a more powerful cancer preventive than previously thought
Drug Development - Chemist's approach to anticancer compounds makes leap from lab to boardroom
Drug Discovery - Elusive cancer killer's deep-sea hideout discovered after a nearly 20-year hunt
Drug Discovery - MethylGene announces oncology collaboration potentially worth $37.5 million
Drug Resistance - Estrogen-responsive RING finger protein limits breast cancer proliferation
Electroporation Technology - Genetronics announces option for a license agreement
Endocrinology - Neurosurgeons implant wafers to treat recurring pituitary tumors
Esophageal Cancer - AEG I and AEG II are two different tumor entities
Esophageal Cancer - Decreasing H. pylori infection prevalence may be factor in rising incidence
Esophageal Cancer - Lymphatic spread in patients with Barrett cancer seems to follow certain rules
Finance - Cancer-focused pharmaceutical company reports revenues of $6.3 million
Finance - Company meets milestones and receives final tranche from $15.67M financing
Finance - Oncology company reports net loss of $17.8M
Finance - Pharmaceutical company reports loss of $0.19 per share
Finance - Revenue increases 117% for cancer drug maker
Finance - Therapeutic antibodies company reports net loss of $0.50 per share
GI Stromal Tumors - Molecular targeting of GIST may revolutionize strategy to treat advanced disease
Gallbladder Cancer - Gallbladder cancer, trends in cholecystectomy rates in Scotland are presented
Gastric Cancer - Phase II study of OSI-7904L begins
Gastroenterology - The magnolia derivative magnolol possesses strong antimetastatic properties
Gene Silencing - Restoration of LKB1 tumor suppressor gene causes apoptosis in cancer cells
Gene Therapy - Modified liposomes improve lentiviral transfection of lymphocytes
Geriatrics - CGA has key role in the decision process in the elderly cancer patient
Germ Cell Tumor - HDCT as primary treatment in 'poor prognosis' patients may be curative option
Glioblastoma - NOVH increases MMP3 expression and cell migration in glioblastoma cells
Glioma - Progressive chiasmatic tumors are best treated by radiotherapy
Gynecology - Lysophosphatidic acid tends to accumulate in the ovarian cancer environment
Gynecology - Performance reviews of gynecologic cytology screening labs suffer diverse forces
Gynecology - Phase I-IIa interim data of ovarian cancer treatment released
HIV/AIDS Cancer - Stem-cell autotransplantation safe for patients with HIV-related lymphoma
Helicobacter Pylori - Gastric plasmacytoma can spontaneously regress following H. pylori therapy
Hematologic Malignancies - Phase IB clinical trial initiated for stem cell transplants
Hematology - Endothelial precursor cells may be a better model for tumor endothelium
Hepatocellular Carcinoma - Activity of STAT-3 signal transduction pathway seems to be needed for HCC growth
Human Solid Cancers - Inactivating mutations of CASPASE-7 gene may lead to loss of apoptotic function
Immunogene Therapy - Interleukins 21 and 23 genes produce an antitumor effect in pancreatic cancer
Immunoglobulin Therapy - High-dose intravenous immunoglobulin therapy for Evans syndrome has stroke risk
Immunology - HBV gene changes precipitate viral breakthrough after liver transplantation
Immunology - Interleukin-2 gene therapy shows early signs of diminishing prostate cancer
Immunology - Poly-G-oligodeoxynucleotides don't augment natural response to mastocytomas
Immunology - Recombinant antibody offers a new approach for halting tumor progression
Leukemia - AML cells overexpress PYST2
Leukemia - CDDO and its derivatives disrupt intracellular redox balance
Leukemia - First part of NDA filed for Clofarabine; data shows promise
Leukemia - Leukemia, lymphoma cells prefer extravasation by means of laminin isoforms 8, 10
Leukemia - Targeted therapy of FLT3 may help the fight against leukemia, other malignancies
Leukemia Risks - Pediatric patients with acute lymphoblastic leukemia have a risk of thrombosis
Liver Cancer - Ablative cancer therapy works better in those with alcohol-related liver disease
Liver Cancer - Outpatient treatment shrinks tumors to acceptable size for laser procedure
Liver Cancer - Viral hepatitis related cancers prevail because of persistent inflammation
Lung Cancer - Lung cancer patients show 50% reduction in tumor size in phase II study
Lung Cancer - Second hand smoke fuels the growth of tumors and their blood vessels
Lung Cancer - TDE2 gene and its expression identified in non-small cell lung cancer
Lung Cancer - Xyotax dose in STELLAR 4 trial amended
Lymphoma Therapy - Salvage allo-SCT effective for lymphoma patients who relapse after auto-SCT
Mammography - Fat-suppression imaging technique unveiled
Melanoma - Suppression of BRAF(V599E) in human melanoma abrogates transformation
Meningiomas - Aspects of vertebral artery at level of dural crossing are presented
Mergers and Acquisitions - Historical Autographs U.S.A. to acquire biomedical device company
Multiple Myeloma - Thalidomide may have no effect on anti-gal antibody, but may immunosuppress
Multiple Myeloma - The angiogenic response in CAM assays is sometimes time-dependent
Multiple Myeloma - Triple stem-cell autotransplants effective for high-risk MM patients
Myelodysplastic Syndrome - Loss of PIASy stem-cell expression may be involved in MDS pathogenesis
Myeloid Leukemia - Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells
Myeloproliferative Disease - IL-3 receptor signaling is dispensable for BCR-ABL-induced MPD
Neurology - Antisense DNA to Bcl-2 enhances glioma cell chemosensitivity
Neuroscience - Dexamethasone suppresses angiogenesis in 9L gliosarcoma
Neuroscience - Leukemia inhibitory factor receptor is a negative regulator of neurites
Neuroscience - Molecular imaging technology is essential for developing biological therapies
Neutropenia - Company to develop improved G-CSF
Non-Hodgkin Lymphoma - Biopharma company commences a phase II study for Pixantrone
Obesity Epidemic - Study implicates obesity as major killer
Oncogenesis - MafA has strong cell transforming ability but is a weak transactivator
Oncogenesis - NF1 modulates the effects of Ras oncogenes
Oncology - Androgen receptor activation promotes apoptosis in cancer cells
Oncology - Gene polymorphisms increase the risk of hepatitis B virus-related liver cancer
Oncology - Interaction between perlecan protein core and progranulin may control cancer
Oncology - RNA assays detect HCV infections better in those with non-Hodgkin lymphoma
Oncology - The molecular signature of bone marrow micrometastasis is distinctive
Oncology - The new agent FK228 is a selective suppressor of angiogenesis factors
Oral Cancer - Green tea polyphenol causes differential oxidative environments in tumor cells
Ovarian Cancer - Intraepithelial neoplasia may be a leading risk factor
Ovarian Cancer - Two-tiered molecular targeting strategy enhances the efficacy of chemotherapy
Pancreatic Cancer - Antimetastatic efficacy of CS-682 confer potential to agent for pancreatic CA
Parotid Cancer - Imaging alone proves unreliable in prediction of histology, tumor grade
Particle Therapy - Companies partner to develop particle therapy solutions
Personnel - Drug development company establishes scientific advisory board
Personnel - Marrow transplant surgeon to chair medical and scientific advisory board
Personnel - Talpaz joins scientific advisory board at oncology firm
Prostate Cancer - Association of prostate cancer risk, human papilloma virus infection studied
Prostate Cancer - Chinese medicinal herb modulates tumor development in mice
Prostate Cancer - Dose of radiation therapy directed to the prostate affects treatment outcome
Prostate Cancer - Inuit are protected against prostate cancer
Prostate Cancer - Modern techniques in the radiotherapy of prostate cancer presented
Prostate Cancer - NAALADase and PSMA inhibitors analyzed
Prostate Cancer - NCI awards $7.6 million to prostate cancer research collaboration
Prostate Cancer - New unique protein marker identified
Prostate Cancer - Prostate biopsy represents safe diagnostic procedure with few complications
Prostate Cancer - Targeting G beta gamma signaling may inhibit prostate tumor formation, growth
Prostate Cancer - The engagement of SPARC with tumor integrins favors cancer metastasis
Prostate Cancer - Use of ultrasound contrast agents for detection, staging of prostate cancer promising
Proteomics - Fibroblast growth factor-2 promotes tumor progression in a prostate cancer model
Quality Assurance - Income important in tracking health status
RNA Interference - Milestone achieved in simultaneously disabling multiple genes
Radiation Exposure - Radiation-related mortality among offspring of atomic bomb survivors examined
Rectal Cancer - NCI to conduct phase II clinical study using TNFerade
Renal Cell Carcinoma - Percutaneous image-guided RFA may become alternative therapy for renal cancers
Renal Cell Carcinoma - Surgical management of renal tumors explored
Renal Disease - Ultrasound contrast may replace CT in complex renal cyst evaluation, follow-up
Renal Disorders - MR techniques for renal imaging reviewed
Retinoblastoma - Amino-terminal domain of retinoblastoma tumor suppressor protein reviewed
Smoking Cessation - Pharmacotherapy can assist in smoking cessation
Spinal Metastases - Population-based study of surgery for spinal metastases provides information
Squamous Cell Carcinoma - SCC produce factors that don't alter dendritic cells, do alter T-cell cytokines
Stem-Cell Research - A mathematical model offers insight into the promise of antiangiogenic therapy
Stem-Cell Transplantation - Mathematical model of PBSC kinetics may improve harvest
Survival Rates - Endometrial carcinomas with lymph node involvement can predict prognosis
Synovial Sarcoma - Awareness of potential for occurrence of oral synovial sarcoma important
Thyroid Cancer - Recurrent papillary thyroid carcinoma treatment in children, adolescents studied
Transplantation - Undetected tumors won't change cancer-related liver transplant outcomes
Tumor Markers - Many kallikreins seem to be candidate tumor markers for many malignancies
Tumors - New technology allows noninvasive treatment of complex shaped tumors
Tumors - Vinblastine halts adrenomedullin-induced angiogenic response
Urothelial Cancer - Gemcitabine/cisplatin reasonable alternative in advanced urothelial cancer
Vector Development - Salmonella delivers genes to tumors in a pilot trial of cancer patients
Virology - Suicide gene expression halts runaway vector infection
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