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Cancer Weekly

Susan Hasty, Publisher

Table of Contents . . . November 18th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Weekly | Other Publications

Cancer Risk Factors - Intraepithelial neoplasia may be leading risk factor for prostate cancer

Metastasis - Stem cells shed light on cancer's spread

Cancer Therapy - Cancer cell telomerase inhibition doesn't compromise chemotherapy

Intestinal Lymphoma - Free perforation can occur in intestinal lymphoma and celiac disease

Prostate Cancer - Dose of PTEN protein found to determine progression of disease

Prostate Cancer - Vector carrying diphtheria toxin A diminishes cancer lesions

AIDS Vaccine - New $16.8M NIH award supports development of vaccine

Alternative Medicine - Ginger curbs tumor growth in mice

Anemia Therapy - Darbepoetin alfa is novel erythropoiesis-stimulating protein

Anticancer Agents - Bisdioxopiperazines target ATP-bound topoisomerase II

Anticancer Therapy - Rigorous trials of mistletoe extracts fail to demonstrate efficacy of therapy

Anticancer Therapy - SMF and anti-neoplastic chemotherapy appear safe together

Barrett Carcinoma - Jejunal interposition after distal esophageal resection shows good function

Barrett Esophagus - Barrett esophagus is excellent model to study early neoplastic progression

Bladder Cancer - Bladder cancer detected by high-volume molecular analysis of urine sediment

Bladder Cancer - Proteomics-based test available in U.S. for diagnosis of bladder cancer

Breast Cancer - A neural survival factor is a candidate oncogene in breast cancer

Breast Cancer - Abraxane data to be presented at San Antonio Breast Cancer Conference

Breast Cancer - Alcohol use boosts risk of hormonally sensitive breast cancers in older women

Breast Cancer - An RNA molecule functions as a tumor suppressor in human breast cancer

Breast Cancer - BRC repeat, RAD51 sequence conservation shows import of BRCA2-RAD51 interactions

Breast Cancer - BRCA1 might function as a molecular scaffold for p53 response

Breast Cancer - Fewer than half of senior women receive radiation therapy after lumpectomy

Breast Cancer - Gene expression analyzed in as few as 100 breast cells from high-risk women

Breast Cancer - Genetic polymorphisms in ER-alpha gene may play role in breast cancer etiology

Breast Cancer - Genetics company identifies novel genetic risk markers for breast cancer

Breast Cancer - Guidelines offer basis for timely mortality reduction of breast cancer

Breast Cancer - High levels of saturated fat, meat intake may slightly increase disease risk

Breast Cancer - Human breast tumors aberrantly express lipoxygenases and cyclooxygenase-2

Breast Cancer - Region-based wavelet coding methods improve the utility of digital mammography

Breast Cancer - Short trinucleotide repeat genotypes of AR gene protect against breast cancer

Breast Cancer - Smokers with breast cancer twice as likely to die than non-smoking patients

Breast Cancer - Study says HRT should be discontinued at diagnosis of breast cancer

Breast Cancer - Tamoxifen can induce, support changes that lead to altered ERalpha expression

Breast Cancer - Tc99m-HMPAO encapsulating VIP-SSL can be used for imaging breast cancer

Breast Cancer - Topotecan may be promising therapy for recurrent disease

Breast Cancer - Two companies collaborating on breast cancer vaccine

Breast Cancer Incidence - Traditional Japanese dietary factors may protect against breast cancer

Breast Cancer Model - Mitoxantrone-loaded microspheres for intratumoral chemotherapy improved survival

Breast Cancer Screening - California mammography rates show regional and ethnic disparities

Breast Cancer and Fertility - Cancer organizations partner to address fertility

Cancer Care Funding - Senators and cancer community leaders fight proposed cancer care cuts

Cancer Detection - French hospital begins clinical evaluation of RECAF cancer detection kits

Cancer Diagnostics - Scientists test protein as early cancer detection agent

Cancer Metastasis - Tie-1 monoclonal antibodies detect angiogenesis in metastatic cancers

Cancer Prevention - Nutrition's role in cancer prevention still needs more study

Cancer Prevention - Pomegranate fruit extract is a novel agent against skin cancer in mice

Cancer Prevention - Research finds tumor preventive qualities, damage reversal, in green tea

Cancer Research - Hutchinson Cancer Center to explore use of nanotechnology tools

Cancer Research - IBC Pharmaceuticals enters research collaboration with Schering, AG

Cancer Risk - Understanding lifestyle changes may provide new insight in cancer prevention

Cancer Therapy - Anti-mouse VEGFR2 antibodies are useful for vascular targeting and imaging

Cancer Therapy - Company publishes results of studies on the mechanism of action of Virulizin

Cancer Therapy - Immunotherapy and antiangiogenic therapy combine to reject tumors

Cancer Therapy - Results of phase I clinical trial of GCS-100 announced

Cancer Treatment - FDA grants Fast Track Designation for HCC treatment

Cancer Treatments - Taiwan-based companies jointly develop novel cancer treatment

Cancer Vaccine - Clinical application of dendritic cells in cancer vaccines reviewed

Cancer Vaccine - Dendritic cell vaccine generates anti-B16BL6 melanoma immunity in mice

Cancer Vaccine - GMCSF gene modified tumor vaccine shows promise in advanced lung cancer

Cancer Vaccine - Individualized human scFv vaccines produced in plants

Cancer-induced Retinopathy - Antirecoverin antibodies in response to tumor don't guarantee retinopathy

Carcinogens - Ionizing radiation induces heritable disruption of epithelial cell interactions

Cardiology - The depictions of tumor vessel physiology on MRI should not be misconstrued

Cardiomyopathy - Cardiac mitochondria may be key in doxorubicin-induced cardiac failure

Cervical Cancer - Cancer center offers DNAwithPap Test for adjunctive cervical screening

Cervical Cancer - Final guidance issued on use of liquid-based cytology in U.K.

Cervical Cancer - Pap smear discrepancies suggest the need for better sample evaluation

Cigarette Smoke - EHC produces a much different smoke from standard cigarette

Cisplatin - Apoptosis markers show there can be cochlear damage from cisplatin

Collaborations - Alliance to offer portable radiation oncology system

Collaborations - Research alliance with Merck targets

Colon Cancer - BRAF mutations are not a consequence of defective mismatch repair per se

Colon Cancer - CDX2 upregulates transcription of the p21/WAF1/CIP1 gene

Colon Cancer - Lymph node staging guidelines of sigmoid, rectum adenocarcinoma evaluated

Colon Cancer - Overexpression of the beta-catenin binding domain of Cad5CD kills HT29 cells

Colon Cancer - TR3 translocation may initiate apoptotic cascade in colon cancer cells

Colorectal Carcinoma - Unique CIs were present in a subset of MSI-H colorectal carcinomas

DNA Damage - Prkdc does not seem to be susceptibility factor for acute benzene toxicity

Dermatology - Photodynamic therapy helps acne, rosacea, sun damage

Diagnostics - 510k clearance granted for patient positioning technology

Diagnostics - Burning mouth syndrome does not appear to be indicative of underlying cancer

Disease Prevention - Four servings daily of fruits, veggies can halve women's breast cancer risk

Disease Prevention - Healthy living may be a more powerful cancer preventive than previously thought

Drug Development - Chemist's approach to anticancer compounds makes leap from lab to boardroom

Drug Discovery - Elusive cancer killer's deep-sea hideout discovered after a nearly 20-year hunt

Drug Discovery - MethylGene announces oncology collaboration potentially worth $37.5 million

Drug Resistance - Estrogen-responsive RING finger protein limits breast cancer proliferation

Electroporation Technology - Genetronics announces option for a license agreement

Endocrinology - Neurosurgeons implant wafers to treat recurring pituitary tumors

Esophageal Cancer - AEG I and AEG II are two different tumor entities

Esophageal Cancer - Decreasing H. pylori infection prevalence may be factor in rising incidence

Esophageal Cancer - Lymphatic spread in patients with Barrett cancer seems to follow certain rules

Finance - Cancer-focused pharmaceutical company reports revenues of $6.3 million

Finance - Company meets milestones and receives final tranche from $15.67M financing

Finance - Oncology company reports net loss of $17.8M

Finance - Pharmaceutical company reports loss of $0.19 per share

Finance - Revenue increases 117% for cancer drug maker

Finance - Therapeutic antibodies company reports net loss of $0.50 per share

GI Stromal Tumors - Molecular targeting of GIST may revolutionize strategy to treat advanced disease

Gallbladder Cancer - Gallbladder cancer, trends in cholecystectomy rates in Scotland are presented

Gastric Cancer - Phase II study of OSI-7904L begins

Gastroenterology - The magnolia derivative magnolol possesses strong antimetastatic properties

Gene Silencing - Restoration of LKB1 tumor suppressor gene causes apoptosis in cancer cells

Gene Therapy - Modified liposomes improve lentiviral transfection of lymphocytes

Geriatrics - CGA has key role in the decision process in the elderly cancer patient

Germ Cell Tumor - HDCT as primary treatment in 'poor prognosis' patients may be curative option

Glioblastoma - NOVH increases MMP3 expression and cell migration in glioblastoma cells

Glioma - Progressive chiasmatic tumors are best treated by radiotherapy

Gynecology - Lysophosphatidic acid tends to accumulate in the ovarian cancer environment

Gynecology - Performance reviews of gynecologic cytology screening labs suffer diverse forces

Gynecology - Phase I-IIa interim data of ovarian cancer treatment released

HIV/AIDS Cancer - Stem-cell autotransplantation safe for patients with HIV-related lymphoma

Helicobacter Pylori - Gastric plasmacytoma can spontaneously regress following H. pylori therapy

Hematologic Malignancies - Phase IB clinical trial initiated for stem cell transplants

Hematology - Endothelial precursor cells may be a better model for tumor endothelium

Hepatocellular Carcinoma - Activity of STAT-3 signal transduction pathway seems to be needed for HCC growth

Human Solid Cancers - Inactivating mutations of CASPASE-7 gene may lead to loss of apoptotic function

Immunogene Therapy - Interleukins 21 and 23 genes produce an antitumor effect in pancreatic cancer

Immunoglobulin Therapy - High-dose intravenous immunoglobulin therapy for Evans syndrome has stroke risk

Immunology - HBV gene changes precipitate viral breakthrough after liver transplantation

Immunology - Interleukin-2 gene therapy shows early signs of diminishing prostate cancer

Immunology - Poly-G-oligodeoxynucleotides don't augment natural response to mastocytomas

Immunology - Recombinant antibody offers a new approach for halting tumor progression

Leukemia - AML cells overexpress PYST2

Leukemia - CDDO and its derivatives disrupt intracellular redox balance

Leukemia - First part of NDA filed for Clofarabine; data shows promise

Leukemia - Leukemia, lymphoma cells prefer extravasation by means of laminin isoforms 8, 10

Leukemia - Targeted therapy of FLT3 may help the fight against leukemia, other malignancies

Leukemia Risks - Pediatric patients with acute lymphoblastic leukemia have a risk of thrombosis

Liver Cancer - Ablative cancer therapy works better in those with alcohol-related liver disease

Liver Cancer - Outpatient treatment shrinks tumors to acceptable size for laser procedure

Liver Cancer - Viral hepatitis related cancers prevail because of persistent inflammation

Lung Cancer - Lung cancer patients show 50% reduction in tumor size in phase II study

Lung Cancer - Second hand smoke fuels the growth of tumors and their blood vessels

Lung Cancer - TDE2 gene and its expression identified in non-small cell lung cancer

Lung Cancer - Xyotax dose in STELLAR 4 trial amended

Lymphoma Therapy - Salvage allo-SCT effective for lymphoma patients who relapse after auto-SCT

Mammography - Fat-suppression imaging technique unveiled

Melanoma - Suppression of BRAF(V599E) in human melanoma abrogates transformation

Meningiomas - Aspects of vertebral artery at level of dural crossing are presented

Mergers and Acquisitions - Historical Autographs U.S.A. to acquire biomedical device company

Multiple Myeloma - Thalidomide may have no effect on anti-gal antibody, but may immunosuppress

Multiple Myeloma - The angiogenic response in CAM assays is sometimes time-dependent

Multiple Myeloma - Triple stem-cell autotransplants effective for high-risk MM patients

Myelodysplastic Syndrome - Loss of PIASy stem-cell expression may be involved in MDS pathogenesis

Myeloid Leukemia - Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells

Myeloproliferative Disease - IL-3 receptor signaling is dispensable for BCR-ABL-induced MPD

Neurology - Antisense DNA to Bcl-2 enhances glioma cell chemosensitivity

Neuroscience - Dexamethasone suppresses angiogenesis in 9L gliosarcoma

Neuroscience - Leukemia inhibitory factor receptor is a negative regulator of neurites

Neuroscience - Molecular imaging technology is essential for developing biological therapies

Neutropenia - Company to develop improved G-CSF

Non-Hodgkin Lymphoma - Biopharma company commences a phase II study for Pixantrone

Obesity Epidemic - Study implicates obesity as major killer

Oncogenesis - MafA has strong cell transforming ability but is a weak transactivator

Oncogenesis - NF1 modulates the effects of Ras oncogenes

Oncology - Androgen receptor activation promotes apoptosis in cancer cells

Oncology - Gene polymorphisms increase the risk of hepatitis B virus-related liver cancer

Oncology - Interaction between perlecan protein core and progranulin may control cancer

Oncology - RNA assays detect HCV infections better in those with non-Hodgkin lymphoma

Oncology - The molecular signature of bone marrow micrometastasis is distinctive

Oncology - The new agent FK228 is a selective suppressor of angiogenesis factors

Oral Cancer - Green tea polyphenol causes differential oxidative environments in tumor cells

Ovarian Cancer - Intraepithelial neoplasia may be a leading risk factor

Ovarian Cancer - Two-tiered molecular targeting strategy enhances the efficacy of chemotherapy

Pancreatic Cancer - Antimetastatic efficacy of CS-682 confer potential to agent for pancreatic CA

Parotid Cancer - Imaging alone proves unreliable in prediction of histology, tumor grade

Particle Therapy - Companies partner to develop particle therapy solutions

Personnel - Drug development company establishes scientific advisory board

Personnel - Marrow transplant surgeon to chair medical and scientific advisory board

Personnel - Talpaz joins scientific advisory board at oncology firm

Prostate Cancer - Association of prostate cancer risk, human papilloma virus infection studied

Prostate Cancer - Chinese medicinal herb modulates tumor development in mice

Prostate Cancer - Dose of radiation therapy directed to the prostate affects treatment outcome

Prostate Cancer - Inuit are protected against prostate cancer

Prostate Cancer - Modern techniques in the radiotherapy of prostate cancer presented

Prostate Cancer - NAALADase and PSMA inhibitors analyzed

Prostate Cancer - NCI awards $7.6 million to prostate cancer research collaboration

Prostate Cancer - New unique protein marker identified

Prostate Cancer - Prostate biopsy represents safe diagnostic procedure with few complications

Prostate Cancer - Targeting G beta gamma signaling may inhibit prostate tumor formation, growth

Prostate Cancer - The engagement of SPARC with tumor integrins favors cancer metastasis

Prostate Cancer - Use of ultrasound contrast agents for detection, staging of prostate cancer promising

Proteomics - Fibroblast growth factor-2 promotes tumor progression in a prostate cancer model

Quality Assurance - Income important in tracking health status

RNA Interference - Milestone achieved in simultaneously disabling multiple genes

Radiation Exposure - Radiation-related mortality among offspring of atomic bomb survivors examined

Rectal Cancer - NCI to conduct phase II clinical study using TNFerade

Renal Cell Carcinoma - Percutaneous image-guided RFA may become alternative therapy for renal cancers

Renal Cell Carcinoma - Surgical management of renal tumors explored

Renal Disease - Ultrasound contrast may replace CT in complex renal cyst evaluation, follow-up

Renal Disorders - MR techniques for renal imaging reviewed

Retinoblastoma - Amino-terminal domain of retinoblastoma tumor suppressor protein reviewed

Smoking Cessation - Pharmacotherapy can assist in smoking cessation

Spinal Metastases - Population-based study of surgery for spinal metastases provides information

Squamous Cell Carcinoma - SCC produce factors that don't alter dendritic cells, do alter T-cell cytokines

Stem-Cell Research - A mathematical model offers insight into the promise of antiangiogenic therapy

Stem-Cell Transplantation - Mathematical model of PBSC kinetics may improve harvest

Survival Rates - Endometrial carcinomas with lymph node involvement can predict prognosis

Synovial Sarcoma - Awareness of potential for occurrence of oral synovial sarcoma important

Thyroid Cancer - Recurrent papillary thyroid carcinoma treatment in children, adolescents studied

Transplantation - Undetected tumors won't change cancer-related liver transplant outcomes

Tumor Markers - Many kallikreins seem to be candidate tumor markers for many malignancies

Tumors - New technology allows noninvasive treatment of complex shaped tumors

Tumors - Vinblastine halts adrenomedullin-induced angiogenic response

Urothelial Cancer - Gemcitabine/cisplatin reasonable alternative in advanced urothelial cancer

Vector Development -  Salmonella delivers genes to tumors in a pilot trial of cancer patients

Virology - Suicide gene expression halts runaway vector infection

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