Cancer Therapy

Cancer cell telomerase inhibition doesn't compromise chemotherapy

Published in Cancer Weekly, November 18th, 2003

Cancer cell telomerase inhibition doesn't compromise chemotherapy.

According to recent research from the United States, "telomerase is expressed in most types of tumor cells but not in most somatic cells, suggesting that telomerase inhibitors may be a powerful new approach to cancer chemotherapy. Here we explore this hypothesis by treating cultured human tumor cells with a 2'-O-methoxyethyl oligonucleotide that binds the telomerase RNA template and acts as a potent inhibitor. Treatment of DU145 (Rb-, p53-) and LNCaP (Rb+, p53) cells causes telomeres to shorten and cell proliferation to stop."

"Decreased cell proliferation in culture is not observed...

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Source: Cancer Weekly (2003-11-18)

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